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GLASS

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GPCR

Name	G-protein coupled receptor family C group 6 member A
Species	Mus musculus (Mouse)
Gene	Gprc6a
Synonym	G protein-coupled receptor G protein-coupled receptor, class C, group 6, member A G protein-coupled receptor, family C, group 6, member A GPCR6A GPRC6 receptor
Disease	N/A for non-human GPCRs
Length	928
Amino acid sequence	MALLITVVTCFMIILDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRRPQIQKCAGFEISVFLQTLAMIHSIEMINNSTLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVVFQCDYSSYMPRVKAVIGAGYSETSIAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWIGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFTKAIERKISKIWIASDNWSTATKIITIPNVKKLGKVVGFAFRRGNTSSFHSFLQTLHMYPNDNNKPLHEFAMLVSACKYIKDGDLSQCISNYSQATLTYDTTKTIENHLFKRNDFLWHYTEPGLIYSIQLAVFALGHAIRDLCQARDCKKPNAFQPWELLAVLKNVTFTDGRNSFHFDAHGDLNTGYDVVLWKETNGLMTVTKMAEYDLQRDVFITTNQETKHEFRKLKQILSKCSKECSPGQMKKATGSQHSCCYECVSCPENHYSNETDMDHCLLCNNETHWAPVRSTTCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAIGIIFTRNLKTPVVKSSGGLVVCYVMLICHALNFASTGFFIGEPQDFACKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPKLTMFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPSVEENISLPRVIILECEEGSALAFGTMLGYITVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYTTTFGKYLPAVEIIVILISNYGILCCIFFPKCYIILCKQKTNTKSAFLQMVYNYSAHSVDSLALSHVSLDSTSYDTATTNQSPGNKMTACQNDNHLPAQVLPHTGTAKTIKASKTLRQKRSSSI
UniProt	Q8K4Z6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3347255
IUPHAR	55
DrugBank	N/A

Ligand

Name	L-arginine
Molecular formula	C6H14N4O2
IUPAC name	(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid
Molecular weight	174.204
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-4.2
Synonyms	LS-170346 MolPort-006-109-239 NCGC00024715-05 Poly(L-arginine) SBI-0207062.P001 Tocris-0663 US9144538, L-Arginine L-Aryginine,(S) bmse000899 (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoate CHEBI:16467 1332377-47-5 Detoxargin 2-Amino-5-Guanidnovaleric Acid EU-0100077 InChI=1/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s A837397 L-(+) arginine AC1Q4U8N L-Arg AN-20586 L-Arginine, BioUltra, >=99.5% (NT) Arginine (USP/INN) Argininum (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid L-Ornithine, N5-(aminoiminomethyl)- M02981 NCGC00015064-02 NSC 206269 R-gene 10 SR-01000075479 Tox21_500077 ZINC1532525 L-Arginine, SAJ special grade, >=98.0% (S)-(+)-arginine C00062 (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid CTK7D2126 154605-63-7 DSSTox_RID_79618 3h-l-arginine H-Arg 94ZLA3W45F L(+) arginine AB1002666 L-a-Amino-d-guanidinovalerate AK-81231 L-Arginine (9CI) Argamine L-Arginine, labeled with tritium Arginine [USAN:INN] (2S)-2-amino-5-(carbamimidamido)pentanoic acid AS-14190 Lopac0_000077 Minophagen A NCGC00024715-03 Pentanoic acid, 2-amino-5-((aminoiminomethyl)amino)-, (S)- RTR-032432 SR-01000597671-1 UNII-FL26NTK3EP component ODKSFYDXXFIFQN-BYPYZUCNSA-N L-Arginine, Vetec(TM), 98.5% BDBM21959 (S)-2-Amino-5-guanidinopentanoic acid CCG-204172 1-Amino-4-guanidovaleric acid D0O3VV 2-amino-5-guanidinovalerate EINECS 200-811-1 5-[(aminoiminomethyl)amino]-L-Norvaline HSDB 1429 A50124 L(+)-Arginine; AC1Q4U8L L-alpha-Amino-delta-guanidinovaleric acid AM81500 L-Arginine, 99%, FCC, FG arginine ARGININE, L- (2S)-2-amino-5-guanidino-pentanoic acid LS-185750 N5-(aminoiminomethyl)-L-Ornithine NCGC00260762-01 Polyarginine SC-06613 Tox21_113046 W-104410 L-Arginine, PharmaGrade, Ajinomoto, EP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture L-Norvaline, 5-((aminoiminomethyl)amino)- (2S)-2-azanyl-5-[bis(azanyl)methylideneamino]pentanoic acid bmse000919 (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoic acid 142-49-4 DSSTox_CID_21056 25212-18-4 FT-0627695 74-79-3 K277 AB0014136 L-(+)-Arginine AI3-24165 L-Arginin ANW-36527 L-Arginine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0% Arginine (VAN) Argininum [INN-Latin] Levargin MCULE-5108123240 NCGC00024715-01 NSC203450 R-Gene 10 (Pharmacia Corp.) SR-01000075479-1 TR-032432 L-Arginine, United States Pharmacopeia (USP) Reference Standard (S)-2-Amino-5-((aminoiminomethyl)amino)pentanoic acid C6H14N4O2 (S)-Arginine D02982 154605-67-1 DTXSID6041056 4-04-00-02648 (Beilstein Handbook Reference) H-Arg-OH A 5006 L(+)-Arginine AC-083 L-a-Amino-d-guanidinovaleric acid AKOS006239069 L-Arginine (H-Arg-OH) Arginina L-Arginine, monohydrochloride Arginine [USP:INN] (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid BC204045 LP00077 MolPort-000-000-568 NCGC00024715-04 Pentanoic acid, 2-amino-5-[(aminoiminomethyl)amino]-, (S)- S-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid ST2414597 US9138393, L-Arginine L-Arginine-L-Glutamate 2-Amino-Pentanedoic Acid bmse000029 (S)-2-Amino-5-guanidinovaleric acid CCRIS 3609 1-Amino-4-guanidovalerlic acid DB00125 2-amino-5-guanidinovaleric acid Epitope ID:140084 667422-95-9 HY-N0455 A7079 L- AC1Q4U8M L-Amino-4-guanidovaleric acid AN-16154 L-Arginine, 99%, natural, FCC, FG Arginine (L-Arginine) Arginine, L- (8CI) (2S)-2-amino-5-guanidinopentanoic acid LS-21576 NCGC00015064-01 Norvaline, 5-[(aminoiminomethyl)amino]-, (L)- PubChem7933 SCHEMBL1791 Tox21_113046_1 Y-8965 L-Arginine, reagent grade, >=98% L-Norvaline, 5-[(aminoiminomethyl)amino]- (L)-Arginine BRN 1725413 (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate CHEMBL1485 14932-EP2316830A2 DSSTox_GSID_41056 26982-20-7 (hydrochloride) GTPL721 7F15B0C7-356D-45D7-AC33-03AEE4394A0E KB-53124 AB00374192_03 L-2-Amino-5-guanidinopentanoic acid AJ-26775 arg L-Arginine, homopolymer Arginine hydrochloride(USAN) Argivene Lopac-A-5006 MFCD00002635 NCGC00024715-02 ODKSFYDXXFIFQN-BYPYZUCNSA-N RP23641 SR-01000597671 UNII-94ZLA3W45F L-Arginine, Vetec(TM) reagent grade, >=98% BDBM181132 (s)-2-amino-5-guanidino-pentanoic acid CAS-74-79-3 002A635 D0F5DO 1laf EC 200-811-1 4455-52-1 HMS3260O15 A0526 L(+)-Arginine, 98+% AC1L1M9R L-alpha-Amino-delta-guanidinovalerate AKOS015854096 L-Arginine (JP17) Arginina [INN-Spanish] L-Arginine, Pharmaceutical Secondary Standard; Certified Reference Material Arginine, European Pharmacopoeia (EP) Reference Standard (2S)-2-amino-5-carbamimidamidopentanoic acid [ Show all ]
Inchi Key	ODKSFYDXXFIFQN-BYPYZUCNSA-N
Inchi ID	InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
PubChem CID	6322
ChEMBL	CHEMBL1485
IUPHAR	721
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	284000.0 nM	MedChemComm, (2011) 2:11:1120	ChEMBL

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