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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Free fatty acid receptor 2
Species	Homo sapiens (Human)
Gene	FFAR2
Synonym	FFA2R G protein-coupled receptor 43 G-protein coupled receptor 43 GPCR3 GPR43 FFA2 receptor [ Show all ]
Disease	Abortion Diabetes
Length	330
Amino acid sequence	MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProt	O15552
Protein Data Bank	N/A
GPCR-HGmod model	O15552
3D structure model	This predicted structure model is from GPCR-EXP O15552.
BioLiP	N/A
Therapeutic Target Database	T28213
ChEMBL	CHEMBL5493
IUPHAR	226
DrugBank	N/A

Ligand

Name	CHEMBL3353491
Molecular formula	C24H23ClN2O2
IUPAC name	N-[(4-chlorophenyl)methyl]-N,2-dimethyl-1-(naphthalene-1-carbonyl)azetidine-2-carboxamide
Molecular weight	406.91
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.6
Synonyms	BDBM50032294
Inchi Key	LRBPWIBVBMUYDE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H23ClN2O2/c1-24(23(29)26(2)16-17-10-12-19(25)13-11-17)14-15-27(24)22(28)21-9-5-7-18-6-3-4-8-20(18)21/h3-13H,14-16H2,1-2H3
PubChem CID	118719611
ChEMBL	CHEMBL3353491
IUPHAR	N/A
BindingDB	50032294
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3350.0 nM	PMID25380412	BindingDB,ChEMBL

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