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Name | Oxytocin receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Oxtr |
Synonym | OT receptor OT-R OTR |
Disease | N/A for non-human GPCRs |
Length | 388 |
Amino acid sequence | MEGTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAAEGNDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARYLKGSRPGETSVSKKSNSSTFVLSRRSSSQRSCSQPSSA |
UniProt | P70536 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3996 |
IUPHAR | 369 |
DrugBank | N/A |
Name | CHEMBL2369831 |
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Molecular formula | C45H63N13O12S2 |
IUPAC name | (2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-13-benzyl-10-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide |
Molecular weight | 1042.2 |
Hydrogen bond acceptor | 15 |
Hydrogen bond donor | 13 |
XlogP | -2.9 |
Synonyms | Vasopressin, 1-(3-mercaptopropanoic acid)-4-L-threonine-8-D-arginine- Deamino(4-threonine,8-D-arginine)vasopressin Vasopressin, deamino(4-thr-8-arg)- Deamino(4-threonine-8-arginine)vasopressin 58928-37-3 [ Show all ] |
Inchi Key | CLIPIZUAVXBONL-CWRNHFHWSA-N |
Inchi ID | InChI=1S/C45H63N13O12S2/c1-24(59)37-43(69)55-31(21-34(46)61)40(66)56-32(44(70)58-17-6-10-33(58)42(68)53-28(9-5-16-50-45(48)49)38(64)51-22-35(47)62)23-72-71-18-15-36(63)52-29(20-26-11-13-27(60)14-12-26)39(65)54-30(41(67)57-37)19-25-7-3-2-4-8-25/h2-4,7-8,11-14,24,28-33,37,59-60H,5-6,9-10,15-23H2,1H3,(H2,46,61)(H2,47,62)(H,51,64)(H,52,63)(H,53,68)(H,54,65)(H,55,69)(H,56,66)(H,57,67)(H4,48,49,50)/t24-,28+,29+,30+,31+,32+,33+,37+/m1/s1 |
PubChem CID | 73348432 |
ChEMBL | CHEMBL2369831 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 10.2 U/mg | PMID950656 | ChEMBL |
Activity | 19.7 U/mg | PMID950656 | ChEMBL |
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