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Name | Free fatty acid receptor 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | FFAR2 |
Synonym | FFA2R G protein-coupled receptor 43 G-protein coupled receptor 43 GPCR3 GPR43 [ Show all ] |
Disease | Abortion Diabetes |
Length | 330 |
Amino acid sequence | MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE |
UniProt | O15552 |
Protein Data Bank | N/A |
GPCR-HGmod model | O15552 |
3D structure model | This predicted structure model is from GPCR-EXP O15552. |
BioLiP | N/A |
Therapeutic Target Database | T28213 |
ChEMBL | CHEMBL5493 |
IUPHAR | 226 |
DrugBank | N/A |
Name | CHEMBL3353524 |
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Molecular formula | C27H31F3N2O4 |
IUPAC name | 4-[[1-[2-(3,5-dimethylphenyl)acetyl]-2-methylazetidine-2-carbonyl]-[[4-(trifluoromethyl)phenyl]methyl]amino]butanoic acid |
Molecular weight | 504.55 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 4.2 |
Synonyms | BDBM50032350 SCHEMBL11302343 |
Inchi Key | IISRXBZYWKGMAS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H31F3N2O4/c1-18-13-19(2)15-21(14-18)16-23(33)32-12-10-26(32,3)25(36)31(11-4-5-24(34)35)17-20-6-8-22(9-7-20)27(28,29)30/h6-9,13-15H,4-5,10-12,16-17H2,1-3H3,(H,34,35) |
PubChem CID | 70559021 |
ChEMBL | CHEMBL3353524 |
IUPHAR | N/A |
BindingDB | 50032350 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 551.0 nM | PMID25380412 | BindingDB,ChEMBL |
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