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Name | G-protein coupled receptor 39 |
---|---|
Species | Homo sapiens (Human) |
Gene | GPR39 |
Synonym | GPR39 |
Disease | Diabetes |
Length | 453 |
Amino acid sequence | MASPSLPGSDCSQIIDHSHVPEFEVATWIKITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVWVTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIFGAFVVYLVVLLSVAFMCWNMMQVLMKSQKGSLAGGTRPPQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVFVQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAENGFQEHEV |
UniProt | O43194 |
Protein Data Bank | N/A |
GPCR-HGmod model | O43194 |
3D structure model | This predicted structure model is from GPCR-EXP O43194. |
BioLiP | N/A |
Therapeutic Target Database | T88531 |
ChEMBL | CHEMBL3091266 |
IUPHAR | 105 |
DrugBank | N/A |
Name | CHEMBL3342379 |
---|---|
Molecular formula | C19H19FN6O |
IUPAC name | N-[3-fluoro-4-[[[2-(methylamino)-6-pyridin-2-ylpyrimidin-4-yl]amino]methyl]phenyl]acetamide |
Molecular weight | 366.4 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 3 |
XlogP | 2.2 |
Synonyms | BDBM50030774 |
Inchi Key | HHYRNIOVCYHYQO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H19FN6O/c1-12(27)24-14-7-6-13(15(20)9-14)11-23-18-10-17(25-19(21-2)26-18)16-5-3-4-8-22-16/h3-10H,11H2,1-2H3,(H,24,27)(H2,21,23,25,26) |
PubChem CID | 118716420 |
ChEMBL | CHEMBL3342379 |
IUPHAR | N/A |
BindingDB | 50030774 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.35 nM | PMID25313322 | BindingDB |
EC50 | 0.35 nM | PMID25313322 | ChEMBL |
EC50 | 1.0 nM | PMID25313322 | ChEMBL |
EC50 | 1.0 nM | PMID25313322 | BindingDB |
Efficacy | 55.0 % | PMID25313322 | ChEMBL |
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