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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesMus musculus (Mouse)
GeneGpr119
SynonymG protein-coupled receptor 119
G-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPCR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length335
Amino acid sequenceMESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProtQ7TQP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5263
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3358013
Molecular formulaC23H29FN6O4S
IUPAC name5-[(3R)-4-[5-[[2-fluoro-4-(methylsulfonylmethyl)phenyl]methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole
Molecular weight504.581
Hydrogen bond acceptor11
Hydrogen bond donor0
XlogP3.1
SynonymsBDBM50103551
Inchi KeyHGOCZXVINVMQGD-MRXNPFEDSA-N
Inchi IDInChI=1S/C23H29FN6O4S/c1-15(2)21-27-23(34-28-21)29-7-8-30(16(3)12-29)22-25-10-19(11-26-22)33-13-18-6-5-17(9-20(18)24)14-35(4,31)32/h5-6,9-11,15-16H,7-8,12-14H2,1-4H3/t16-/m1/s1
PubChem CID118722586
ChEMBLCHEMBL3358013
IUPHARN/A
BindingDB50103551
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50160.0 nMPMID25286150BindingDB,ChEMBL
Intrinsic activity66.0 %PMID25286150ChEMBL

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