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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	MLS000069104
Molecular formula	C17H17N3O3
IUPAC name	ethyl 2-(2-methyl-7-oxo-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-5-yl)acetate
Molecular weight	311.341
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	1.8
Synonyms	CHEMBL1521564 MCULE-2962375771 STK211471 AKOS000599234 ethyl (7-hydroxy-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-5-yl)acetate MolPort-000-837-187 ZINC100147630 BAS 05235828 ethyl 2-(2-methyl-7-oxo-3-phenyl-4,8-dihydropyrazolo[1,5-a]pyrimidin-5-yl)acet ate SR-01000368046-1 2-(2-methyl-7-oxo-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-5-yl)acetic acid ethyl ester cid_654182 STK848580 726199-64-0 AKOS002530485 ethyl 2-(2-methyl-7-oxidanylidene-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-5-yl)ethanoate SMR000013219 ZINC8577875 (2-Methyl-7-oxo-3-phenyl-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)-acetic acid BDBM37624 HMS2327A18 ST063429 2-(7-keto-2-methyl-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-5-yl)acetic acid ethyl ester ethyl (2-methyl-7-oxo-3-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-5-yl)acetate MolPort-000-510-823 UNM000003590301 AC1LCQ0J AKOS005628361 ethyl 2-(2-methyl-7-oxo-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-5-yl)acetate SR-01000368046 (2-Methyl-7-oxo-3-phenyl-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)-acetic acid ethyl ester [ Show all ]
Inchi Key	CKWZTVSSDLNIRW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H17N3O3/c1-3-23-15(22)10-13-9-14(21)20-17(18-13)16(11(2)19-20)12-7-5-4-6-8-12/h4-9,19H,3,10H2,1-2H3
PubChem CID	654182
ChEMBL	N/A
IUPHAR	N/A
BindingDB	37624
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<40300.0 nM	N/A	BindingDB

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