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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Free fatty acid receptor 1
Species	Homo sapiens (Human)
Gene	FFAR1
Synonym	FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor
Disease	Type 2 diabetes Non-insulin dependent diabetes Diabetes
Length	300
Amino acid sequence	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProt	O14842
Protein Data Bank	5tzy, 5tzr
GPCR-HGmod model	O14842
3D structure model	This structure is from PDB ID 5tzy.
BioLiP	BL0380462, BL0380463, BL0380464
Therapeutic Target Database	T25608
ChEMBL	CHEMBL4422
IUPHAR	225
DrugBank	BE0000688

Ligand

Name	CHEMBL3330550
Molecular formula	C33H31FN2O3
IUPAC name	2-[2-[4-[[4-(2-fluoro-5-methoxyphenyl)-2-methylphenyl]methyl]phenyl]-4-methyl-5-phenyl-3,4-dihydropyrazol-3-yl]acetic acid
Molecular weight	522.62
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	7.6
Synonyms	BDBM50102727 SCHEMBL15740202
Inchi Key	BICVZUYPVRKWQB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C33H31FN2O3/c1-21-17-26(29-19-28(39-3)15-16-30(29)34)12-11-25(21)18-23-9-13-27(14-10-23)36-31(20-32(37)38)22(2)33(35-36)24-7-5-4-6-8-24/h4-17,19,22,31H,18,20H2,1-3H3,(H,37,38)
PubChem CID	73891117
ChEMBL	CHEMBL3330550
IUPHAR	N/A
BindingDB	50102727
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6.0 nM	PMID25264476, PMID27825762	ChEMBL
EC50	6.0 nM	PMID25264476, PMID27825762	BindingDB
EC50	6470.0 nM	PMID25264476	BindingDB,ChEMBL

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