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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3353744
Molecular formulaC29H33FO7S
IUPAC name2-[4-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2-fluorophenoxy]-2-methylpropanoic acid
Molecular weight544.634
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP5.7
SynonymsN/A
Inchi KeyBGXWTSFJQJRSNR-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H33FO7S/c1-19-14-24(35-12-7-13-38(5,33)34)15-20(2)27(19)22-9-6-8-21(16-22)18-36-23-10-11-26(25(30)17-23)37-29(3,4)28(31)32/h6,8-11,14-17H,7,12-13,18H2,1-5H3,(H,31,32)
PubChem CID118719723
ChEMBLCHEMBL3353744
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ratio3.06 -PMID25481394ChEMBL

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