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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Follicle-stimulating hormone receptor
Species	Homo sapiens (Human)
Gene	FSHR
Synonym	Follitropin receptor FSH receptor FSH-R LGR1
Disease	Female infertility African trypanosomiasis Contraception Ovarian cancer
Length	695
Amino acid sequence	MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
UniProt	P23945
Protein Data Bank	4mqw
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mqw.
BioLiP	BL0274372
Therapeutic Target Database	T68334
ChEMBL	CHEMBL2024
IUPHAR	N/A
DrugBank	BE0000387

Ligand

Name	CHEMBL279759
Molecular formula	C29H40N2O5
IUPAC name	(3S,6S)-1-heptyl-4,6-dimethyl-3-[[4-(3,4,5-trimethoxyphenyl)phenyl]methyl]piperazine-2,5-dione
Molecular weight	496.648
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	5.9
Synonyms	BDBM50142657 SCHEMBL6140288 (3S,6S)-1-Heptyl-4,6-dimethyl-3-(3'',4'',5''-trimethoxy-biphenyl-4-ylmethyl)-piperazine-2,5-dione
Inchi Key	CJJTWLZNHTUYBS-RDPSFJRHSA-N
Inchi ID	InChI=1S/C29H40N2O5/c1-7-8-9-10-11-16-31-20(2)28(32)30(3)24(29(31)33)17-21-12-14-22(15-13-21)23-18-25(34-4)27(36-6)26(19-23)35-5/h12-15,18-20,24H,7-11,16-17H2,1-6H3/t20-,24-/m0/s1
PubChem CID	44293289
ChEMBL	CHEMBL279759
IUPHAR	N/A
BindingDB	50142657
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	25.0 nM	PMID15026057	BindingDB,ChEMBL
EC50	32.0 nM	PMID15026057	BindingDB,ChEMBL
Efficacy	54.0 %	PMID15026057	ChEMBL

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