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GPCR

Name	Alpha-2B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2B
Synonym	alpha2-C2 alpha2B alpha2B-adrenoceptor Alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor alpha-2B adrenergic receptor Alpha-2 adrenergic receptor subtype C2 adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 ADRA2L1 Adra-2b [ Show all ]
Disease	Neuropathic pain Alcohol use disorders
Length	450
Amino acid sequence	MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
UniProt	P18089
Protein Data Bank	N/A
GPCR-HGmod model	P18089
3D structure model	This predicted structure model is from GPCR-EXP P18089.
BioLiP	N/A
Therapeutic Target Database	T41580
ChEMBL	CHEMBL1942
IUPHAR	26
DrugBank	BE0000572

Ligand

Name	l-ascorbic acid
Molecular formula	C6H8O6
IUPAC name	(2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one
Molecular weight	176.124
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-1.6
Synonyms	3466-EP2311453A1 Magnorbin 3466-EP2270011A1 Hex-2-enonic acid gamma-lactone, L-threo- 3466-EP2314295A1 NCGC00091517-02 3466-EP2275413A1 IDO-C 3466-EP2316457A1 NSC 33832 3466-EP2284153A2 Kyselina askorbova [Czech] 3466-EP2316833A1 Redoxon 3466-EP2287148A2 L-3-Ketothreohexuronic acid lactone 50976-75-5 RTR-032643 3466-EP2292227A2 L-Ascorbic acid, analytical standard Secorbate 3466-EP2295416A2 L-Ascorbic acid, JIS special grade, >=99.0% (2R)-2-[(1S)-1,2-Dihydroxyethyl]-4,5-dihydroxy-furan-3-one Sunkist 3466-EP2298768A1 L-Ascorbic acid, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., 99.7-100.5% (oxidimetric) 1129294-89-8 D07AHW 3466-EP2301940A1 L-Lyxoascorbic acid 2-(1,2-Dihydroxyethyl)-4,5-dihydroxyfuran-3-one DTXSID5020106 3466-EP2305674A1 L-Threoascorbic acid; Antiscorbutic factor; Vitamin C 3466-EP2269610A2 FCH1121413 Acid Ascorbic Cee-Caps TD ZINC100006770 Adenex Cemagyl Arco-cee Cetane-Caps TC ascorbate cevibid Ascorbic Acid mixture with Vitamin B Complex Cewin Ascorbicab Citriscorb Ascorin Concemin BPBio1_000363 Tox21_302958 623158-95-2 C00072 Viscorin A8158 Ce-Mi-Lin vitamin C 3466-EP2269988A2 Ferrous ascorbate 3466-EP2311807A1 MLS002153776 3466-EP2272537A2 HMS2231N16 3466-EP2314588A1 NCGC00164357-01 3466-EP2281823A2 Juvamine 3466-EP2316825A1 Planavit C 3466-EP2284164A2 L(+)-Ascorbic acid, 99% 3466-EP2377510A1 Rontex 100 3466-EP2287156A1 L-Ascorbic Acid (Vitamin C)-13C6 solution, 500 mug/mL in acetonitrile: water, certified reference material, ampule of 1 mL 56533-05-2 SCHEMBL4430 3466-EP2292612A2 L-Ascorbic acid, BioUltra, >=99.5% (RT) (+)-ascorbate Sodascorbate 3466-EP2295427A1 L-Ascorbic acid, p.a., ACS reagent, 99.0% (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one 3466-EP2301536A1 L-Ascorbic acid, suitable for cell culture, suitable for plant cell culture, >=98% 1428525-25-0 DB00126 3466-EP2305636A1 L-threo-Hex-2-enonic acid, gamma-lactone 3-Keto-1-Gulofuranolactone E-300 3466-EP2308854A1 Laroscorbine vitamin-c Acido ascorbico Ceglion [14C]-ascorbic acid antiscorbic vita min Cenolate Ascor Cetemican Ascorbic acid (JP17/USP/INN) Cevitamate Ascorbic acid [USP:INN:BAN:JAN] CHEMBL40274 Ascorbicin Colascor AX8021086 Tolfrinic C-Level Vasc 885512-24-3 Caswell No. 061B Vitace AB00376923_04 Cebid 3466-EP2270002A1 GTPL4532 3466-EP2311839A1 Natrascorb injectable 3466-EP2272835A1 HY-B0166 3466-EP2314593A1 NCGC00259676-01 3466-EP2284151A2 KSC925A7P 3466-EP2316828A1 Proscorbin 3466-EP2284179A2 L-(+)-Ascorbic Acid 47A605F0-4187-47A8-B0CE-F9E7DA1B0076 Rovimix C 3466-EP2289890A1 L-Ascorbic acid, >=99.0% Scorbu C 3466-EP2295401A2 L-Ascorbic acid, FCC, FG (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one Stuartinic 3466-EP2298742A1 L-Ascorbic acid, powder, cell culture tested, gamma-irradiated 1-Xyloascorbic Acid D00018 3466-EP2301931A1 L-AscorbicAcid 1703051-92-6 DSSTox_GSID_20106 3466-EP2305651A1 L-Threoascorbic acid, Antiscorbutic factor, Vitamin C 3-Oxo-L-gulofuranolactone (enol form) Ester C 3466-EP2308867A2 LS-145 Cecon Xitix Acidum ascorbicum [INN-Latin] Celin Antiscorbutic vitamin Cescorbat Ascorb Cevex Ascorbic Acid DC97SF Cevitan Ascorbic Acid, Monosodium Salt Ciamin Ascorbinsaure component of Endoglobin Forte bmse000182 Tox21_112104_1 C-Span Vicomin C 93398-EP2380568A1 CCRIS 57 Vitacin AC1L1L4T 3466-EP2311455A1 Meri-C 3466-EP2270505A1 Hicee 3466-EP2314584A1 NCGC00091517-03 3466-EP2277848A1 Iron(II) ascorbate 3466-EP2316458A1 Oral Vitamin C 3466-EP2284155A2 L(+)-ascorbate 3466-EP2316837A1 Ribena 3466-EP2287150A2 L-ascorbate 53262-66-1 s3114 3466-EP2292228A1 L-Ascorbic acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99% Semidehydroascorbate 3466-EP2295419A2 L-Ascorbic acid, meets USP testing specifications (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one 3466-EP2298770A1 L-Ascorbic acid, reagent grade 129940-97-2 D0U4HT 3466-EP2305219A1 L-threo-Ascorbic acid 259133-78-3 Duoscorb 3466-EP2305679A1 L-xyloascorbate 3466-EP2269978A2 FEMA No. 2109 Acide ascorbique Cee-Vite ZINC100019304 AK-96407 Cemill Ascoltin Cetane-Caps TD ascorbic acid Cevimin Ascorbic acid [BAN:INN:JAN] CHEBI:29073 Ascorbicap Citrovit Ascorteal SW198791-2 Cortalex BSPBio_000329 UNII-PQ6CK8PD0R 882690-91-7 Cantan Viscorin 100M AB0010512 CE-VI-Sol Vitamin C (Ascorbic acid) 3466-EP2269991A2 gamma-lactone L-threo-Hex-2-enonate 3466-EP2311809A1 MolPort-001-792-501 3466-EP2272822A1 HMS3713A11 3466-EP2314589A1 NCGC00188972-01 3466-EP2284149A1 Kangbingfeng 3466-EP2316826A1 PQ6CK8PD0R 3466-EP2284171A1 L(+)-Ascorbic acid, ACS reagent 3466-EP2380568A1 roscorbi c 3466-EP2289510A1 L-Ascorbic acid solution, 1.0 mg/mL in acetonitrile: water, certified reference material 57304-74-2 SCHEMBL785 3466-EP2292617A1 L-Ascorbic acid, BioXtra, >=99.0%, crystalline (+)-Ascorbic acid Sodium Ascorbate (Ascorbic Acid) 3466-EP2295435A1 L-Ascorbic acid, p.a., ACS reagent, reag. ISO, 99.7% (R)-5-((S)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one 3466-EP2301538A1 L-Ascorbic acid, tested according to Ph.Eur. 14536-17-5 Dora-C-500 3466-EP2305637A2 L-threo-hex-2-enono-1,4-lactone 3-Keto-L-gulofuranolactone E300 3466-EP2308857A1 Lemascorb Cebion Vitamisin Acido ascorbico [INN-Spanish] Ceklin [14C]ascorbic acid Antiscorbic vitamin Cereon ascor-b.i.d Cevalin Ascorbic Acid (L-Ascorbic Acid; Vitamin C) Cevitamic acid Ascorbic acid, British Pharmacopoeia (BP) Reference Standard Chewcee Ascorbin component of Cortalex BCP27915 Tox21_110315 C-Long Vicelat 88845-26-5 Catavin C Vitacee AB00376923_05 3466-EP2308870A2 Magnesium Ascorbicum 3466-EP2270008A1 GTPL4781 3466-EP2311842A2 NCGC00091517-01 3466-EP2272844A1 Hybrin 3466-EP2316452A1 NCI-C54808 3466-EP2284152A2 Kyselina askorbova 3466-EP2316832A1 PubChem18445 3466-EP2287140A2 L-3-ketothreohexuronic acid 50-81-7 RP23765 3466-EP2289892A1 L-Ascorbic acid, ACS reagent, >=99% Scorbu-C 3466-EP2295409A1 L-Ascorbic acid, free radical form (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxy-2,3-dihydrofuran-3-one Suncoat VC 40 3466-EP2298748A2 L-Ascorbic acid, puriss. p.a., >=99.0% (RT) 1018124-03-2 D06NNE 3466-EP2301935A1 L-lyxoascorbate 178101-88-7 DSSTox_RID_75370 3466-EP2305668A1 L-Threoascorbic acid,Antiscorbutic factor,Vitamin C;(R)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one 30208-61-8 Ester-C cee-caps td Xyloascorbic acid, L- Acidum ascorbinicum Cell C ANW-73969 Cetamid Ascorbajen Cevi-Bid Ascorbic acid mixture with Vitamin B Cevitex Ascorbic acid, United States Pharmacopeia (USP) Reference Standard Cipca Ascorbutina component of Ferancee BP-12831 Tox21_202127 C-Vimin Viforcit A0537 Ce lent Vitamin B mixture with vitamin C AC1Q77S6 3466-EP2311805A1 MFCD00064328 3466-EP2272516A2 HMS2096A11 3466-EP2314585A1 NCGC00091517-06 3466-EP2277865A1 Iron-ascorbic acid complexes 3466-EP2316470A2 Parentrovite 3466-EP2284156A2 L(+)-Ascorbic acid 3466-EP2374792A1 Ronotec 100 3466-EP2287153A1 56172-55-5 SC-18563 3466-EP2292592A1 L-Ascorbic acid, AR, >=99.5% SMR001233160 3466-EP2295426A1 L-Ascorbic acid, mixt. with vitamin B (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one 3466-EP2298776A1 L-Ascorbic acid, reagent grade, crystalline 134-03-2 (monosodium salt) Davitamon C 3466-EP2305257A1 l-threo-hex-1-eofuranos-3-ulose 3,4-Dihydroxy-5beta-[(S)-1,2-dihydroxyethyl]furan-2(5H)-one E 300 3466-EP2305683A1 L-Xyloascorbic acid 3466-EP2269985A2 Ferancee Acide ascorbique [INN-French] Cegiolan ZX-AFC000785 Allercorb Cenetone Ascoltin (TN) Cetebe Ascorbic acid (JP15/USP/INN) Cevital Ascorbic acid [INN:BAN:JAN] Ascorbicap (TN) CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorvit Testascorbic CTK8C5077 C 1000 Valeryl fentanyl hydrochloride solution, 100 mug/mL in methanol (as a free base), certified reference material, ampule of 0.5 mL 884381-69-5 Cantaxin VIT0000113 AB00376923 Cebicure Vitamin C,(S) 3466-EP2270000A1 gamma-lactone L-threo-Hex-2-enonic acid 3466-EP2311824A1 Natrascorb 3466-EP2272834A1 HSDB 818 3466-EP2314590A1 NCGC00256504-01 3466-EP2284150A2 KS-00000EU9 3466-EP2316827A1 Prestwick3_000325 3466-EP2284178A2 L-(+)-ascorbate 3eka Roscorbic 3466-EP2289883A1 L-Ascorbic acid, 99% 57606-40-3 Scorbacid 3466-EP2295055A2 L-Ascorbic acid, certified reference material, TraceCERT(R) (+)-Sodium L-ascorbate ST24026436 3466-EP2298735A1 L-Ascorbic acid, plant cell culture tested .Ascorbinsaure 3466-EP2301929A1 L-Ascorbic acid, Vetec(TM) reagent grade, 99% 154170-90-8 DSSTox_CID_106 3466-EP2305648A1 L-Threoascorbic acid 3-Oxo-L-gulofuranolactone EINECS 200-066-2 3466-EP2308861A1 Liqui-Cee Cebione Vitascorbol Acidum ascorbicum Celaskon Antiscorbutic factor Cergona Ascor-B.I.D. Cevatine ascorbic acid (vit C) Cevitamin Ascorbic acid, European Pharmacopoeia (EP) Reference Standard Chromagen Ascorbinsaeure component of E and C-Level BIA0602 Tox21_112104 C-Quin Vicin 89924-69-6 CCG-207946 Vitacimin AB1002440 [ Show all ]
Inchi Key	CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Inchi ID	InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
PubChem CID	54670067
ChEMBL	CHEMBL196
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.5 nM	PMID19243956	ChEMBL

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