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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Gallus gallus (Chicken)
Gene	CHRM4
Synonym	N/A
Disease	N/A for non-human GPCRs
Length	490
Amino acid sequence	MHNLSAQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVRRHKPESRKERKGKSLSFFKAPPVKQNNNNSPKRAVEVKEEVRNGKVDDQPSAQTEATGQQEEKETSNESSTVSMTQTTKDKPTTEILPAGQGQSPAHPRVNPTSKWSKIKIVTKQTGTESVTAIEIVPAKAGASDHNSLSNSRPANVARKFASIARSQVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETCVPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR
UniProt	P17200
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	biperiden
Molecular formula	C21H29NO
IUPAC name	1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
Molecular weight	311.469
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.3
Synonyms	Biperiden [USAN:BAN:INN:JAN] Biperidenum CHEMBL1101 GTPL7128 NCGC00182965-02 1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol Pharmakon1600-01505514 1-{bicyclo[2.2.1]hept-5-en-2-yl}-1-phenyl-3-(piperidin-1-yl)propan-1-ol SR-05000001649 AKOS016008819 Beperiden Biperidene BRD-A00546892-001-01-8 D0B4TN HY-13204A .alpha.-5-Norbornen-2-yl-.alpha.-phenyl-1-piperidinepropanol NCIOpen2_009564 1-Piperidinepropanol, .alpha.-5-norbornen-2-yl-.alpha.-phenyl- Prestwick2_000502 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) [German] VA10409 AC1L1DJT alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol Biperiden hydrochloride Biperideno CCG-213474 DTXSID6022680 LS-116068 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol PDSP1_000821 1-PIPERIDINEPROPANOL, alpha-5-NORBORNEN-2-YL-alpha-PHENYL- SCHEMBL34957 5-Norbornene-2-methanol, .alpha.-phenyl-.alpha.-(2-piperidinoethyl)- Akinophyl AX8116739 Bicyclo[2.2.1]hept-5-ene-2-methanol, .alpha.-phenyl-.alpha.-[2-(1-piperidinyl)ethyl]- Biperiden [USAN:INN:BAN:JAN] Biperidenum [INN-Latin] CS-1797 HMS2093N17 NCGC00182965-03 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1 Prestwick0_000502 1235-82-1 (hydrochloride) SR-05000001649-1 514-65-8 alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol Biperiden (JAN/USP/INN) Biperidene hydrochloride BRN 0290038 KL 373 0FRP6G56LD NSC-759145 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl- SBI-0206797.P001 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol YSXKPIUOCJLQIE-UHFFFAOYSA-N Akineton alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol Biperiden lactate Biperideno [INN-Spanish] CHEBI:3112 EINECS 208-184-6 NCGC00182965-01 1-(Bicyclo(2.2.1)hept-5-en-2alpha-yl)-1-phenyl-3-piperidinopropanol PDSP2_000808 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl- SPBio_002344 5-Norbornene-2-methanol, alpha-phenyl-alpha-(2-piperidinoethyl)- Akinophyl (Salt/Mix) BDBM50240680 Bipariden Biperiden [USP:INN:BAN:JAN] Biperidine D00779 HSDB 7639 .alpha.-(Bicyclo(2.2.1)hept-5-en-2-yl)-.alpha.-phenyl-1-piperidino propanol NCGC00182965-04 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-(1-piperidinyl)-1-propanol # Prestwick1_000502 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) UNII-0FRP6G56LD alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol Biperiden HCl Biperidene [INN-French] C07941 DB00810 L001222 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol NSC759145 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl-, hydrochloride SCHEMBL20229360 5-20-02-00242 (Beilstein Handbook Reference) Akineton (TN) AN-45471 [ Show all ]
Inchi Key	YSXKPIUOCJLQIE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2
PubChem CID	2381
ChEMBL	N/A
IUPHAR	7128
BindingDB	50240680
DrugBank	DB00810
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.7 nM	PMID2250662	BindingDB

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