Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	Dibromosalicil
Molecular formula	C14H8Br2O4
IUPAC name	1,2-bis(5-bromo-2-hydroxyphenyl)ethane-1,2-dione
Molecular weight	400.022
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.7
Synonyms	Dibromsalicil Fungotox (VAN) Salicil, 5,5'-dibromo- 5,2'-dihydroxybibenzoyl 639B873 BRN 3384611 DTXSID20200328 MLS002638309 SMR001547796 1,2-bis(5-bromo-2-hydroxyphenyl)-1,2-ethanedione 5,5'-Dibrom-2,2'-dioxybenzil [German] AKOS027382229 cid_10662 Ethanedione, bis(5-bromo-2-hydroxyphenyl)- (9CI) NSC13235 Z2V3FF4B7F 5,5'-Dibromosalicil Bis(5-bromo-2-hydroxyphenyl)ethanedione Dibrosal HMS3086D19 Salicil,5'-dibromo- 5,2'-dioxybenzil AC1L1VOE CTK8J0096 EINECS 208-351-3 NSC 13235 UNII-Z2V3FF4B7F 1,2-bis(5-bromo-2-hydroxyphenyl)ethane-1,2-dione 5,5'-Dibromo-2,2'-dihydroxybenzil BDBM22753 Dibromosalicyl Fungotox Respectol ZINC1683334 5,2'-dihydroxybenzil 523-88-6 Bis-(5-brom-2-hydroxyphenyl)ethandion Dibrosil LS-144117 SCHEMBL2156880 1,2-bis(5-bromo-2-hydroxy-phenyl)ethane-1,2-dione 5,5'-Dibrom-2,2'-dioxybenzil ACM523886 CHEMBL366205 Degermon Ethanedione, bis(5-bromo-2-hydroxyphenyl)- NSC-13235 WLN: QR DE BVVR BQ EE 1,2-Bis-(5-bromo-2-hydroxy-phenyl)-ethane-1,2-dione 5,5'-Dibromo-2,2'-dihydroxybibenzoyl Benzil-based compound, 31 [ Show all ]
Inchi Key	AAOYLOCWJSLLJU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H8Br2O4/c15-7-1-3-11(17)9(5-7)13(19)14(20)10-6-8(16)2-4-12(10)18/h1-6,17-18H
PubChem CID	10662
ChEMBL	CHEMBL366205
IUPHAR	N/A
BindingDB	22753
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1102.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417