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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 6
Species	Homo sapiens (Human)
Gene	LPAR6
Synonym	Purinergic receptor 5 P2Y5 P2Y purinoceptor 5 P2RY5 oleoyl-L-alpha-lysophosphatidic acid receptor LPA6 receptor LPA-6 LPA receptor 6 RB intron encoded G-protein coupled receptor [ Show all ]
Disease	N/A
Length	344
Amino acid sequence	MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMINLAMSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQGNNASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKPVTLSRSKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLKSKIFDNESAA
UniProt	P43657
Protein Data Bank	N/A
GPCR-HGmod model	P43657
3D structure model	This predicted structure model is from GPCR-EXP P43657.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2331058
IUPHAR	163
DrugBank	N/A

Ligand

Name	1-Hexadecanoyl-sn-glycero-3-phosphate
Molecular formula	C19H39O7P
IUPAC name	[(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate
Molecular weight	410.488
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.0
Synonyms	PA(16:0/0:0) Hexadecanoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester LPA(16:0/0:0) SCHEMBL2935665 (2R)-2-hydroxy-3-(phosphonooxy)propyl palmitate BDBM50430013 Lysophosphatidic acid(16:0/0:0) 1-palmitoyl-sn-glycerol-3-phosphate CHEMBL364797 Palmitin, 1-mono-, 3-(dihydrogen phosphate), L- 7220-34-0 Hexadecanoic acid, 2-hydroxy-3-(phosphonooxy)propyl ester, (R)- LysoPA(16:0/0:0) ZINC8219000 CHEBI:15799 NKO 1-Palmitoyl-sn-glyceryl 3-phosphate CTK2H2733 Palmitoyl lysophosphatidic acid (2R)-2-hydroxy-3-(phosphonooxy)propyl hexadecanoate AC1O4WBH LMGP10050006 Lysophosphatidic acid(16:0) [(2R)-2-hydroxy-3-phosphonooxypropyl] hexadecanoate 1-palmitoyl-sn-glycerol 3-phosphate [ Show all ]
Inchi Key	YNDYKPRNFWPPFU-GOSISDBHSA-N
Inchi ID	InChI=1S/C19H39O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(21)25-16-18(20)17-26-27(22,23)24/h18,20H,2-17H2,1H3,(H2,22,23,24)/t18-/m1/s1
PubChem CID	6419701
ChEMBL	CHEMBL364797
IUPHAR	N/A
BindingDB	50430013
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	930.0 nM	PMID23395664	BindingDB,ChEMBL
EC50	933.25 nM	PMID23395664	ChEMBL
Intrinsic activity	0.25 -	PMID23395664	ChEMBL

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