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GPCR

NameC-X-C chemokine receptor type 3
SpeciesMus musculus (Mouse)
GeneCxcr3
SynonymIP-10 receptor
Interferon-inducible protein 10 receptor
GPR9
G protein-coupled receptor 9
CXCR3
[ Show all ]
DiseaseN/A for non-human GPCRs
Length367
Amino acid sequenceMYLEVSERQVLDASDFAFLLENSTSPYDYGENESDFSDSPPCPQDFSLNFDRTFLPALYSLLFLLGLLGNGAVAAVLLSQRTALSSTDTFLLHLAVADVLLVLTLPLWAVDAAVQWVFGPGLCKVAGALFNINFYAGAFLLACISFDRYLSIVHATQIYRRDPRVRVALTCIVVWGLCLLFALPDFIYLSANYDQRLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRFRAMRLVVVVVAAFAVCWTPYHLVVLVDILMDVGVLARNCGRESHVDVAKSVTSGMGYMHCCLNPLLYAFVGVKFREQMWMLFTRLGRSDQRGPQRQPSSSRRESSWSETTEASYLGL
UniProtO88410
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5200
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1808998
Molecular formulaC25H26N4O3
IUPAC name(6aR,9R)-9-N-(2-hydroxyethyl)-9-N-methyl-7-N-phenyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-7,9-dicarboxamide
Molecular weight430.508
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP1.7
SynonymsBDBM50349640
Inchi KeyYIHFFXWGJWZDBZ-VGOFRKELSA-N
Inchi IDInChI=1S/C25H26N4O3/c1-28(10-11-30)24(31)17-12-20-19-8-5-9-21-23(19)16(14-26-21)13-22(20)29(15-17)25(32)27-18-6-3-2-4-7-18/h2-9,12,14,17,22,26,30H,10-11,13,15H2,1H3,(H,27,32)/t17-,22-/m1/s1
PubChem CID56660099
ChEMBLCHEMBL1808998
IUPHARN/A
BindingDB50349640
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC509.0 nMPMID21764306BindingDB,ChEMBL

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