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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Corticotropin-releasing factor receptor 1
Species	Rattus norvegicus (Rat)
Gene	Crhr1
Synonym	CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor CRF-RA CRF-R1alpha CRF-R1 CRF-R-1 CRF-R CRF 1 receptor Corticotropin-releasing hormone receptor 1 CRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	415
Amino acid sequence	MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProt	P35353
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4649
IUPHAR	212
DrugBank	N/A

Ligand

Name	CHEMBL350784
Molecular formula	C22H20N4O2
IUPAC name	N-[(1R,2S)-2-aminocyclohexyl]-7-oxobenzo[e]perimidine-4-carboxamide
Molecular weight	372.428
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.4
Synonyms	N-[(1R)-2beta-Aminocyclohexane-1beta-yl]-7-oxo-7H-benzo[e]perimidine-4-carboxamide 7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid ((1R,2S)-2-amino-cyclohexyl)-amide BDBM50075923
Inchi Key	YEIPENKZKGYLPU-DLBZAZTESA-N
Inchi ID	InChI=1S/C22H20N4O2/c23-16-7-3-4-8-17(16)26-22(28)15-10-9-14-18-19(24-11-25-20(15)18)12-5-1-2-6-13(12)21(14)27/h1-2,5-6,9-11,16-17H,3-4,7-8,23H2,(H,26,28)/t16-,17+/m0/s1
PubChem CID	15381047
ChEMBL	CHEMBL350784
IUPHAR	N/A
BindingDB	50075923
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID10201844	BindingDB,ChEMBL

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