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GPCR

NameVasopressin V2 receptor
SpeciesRattus norvegicus (Rat)
GeneAvpr2
SynonymAVPR V2
Antidiuretic hormone receptor
ADHR
Renal-type arginine vasopressin receptor
V2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length371
Amino acid sequenceMLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProtQ00788
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3766
IUPHAR368
DrugBankN/A

Ligand

NameCHEMBL1253499
Molecular formulaC33H32Cl3N3O4
IUPAC name4-chloro-3-[(3R)-5-chloro-1-[(2,4-dimethoxyphenyl)methyl]-3-methyl-2-oxoindol-3-yl]-N-ethyl-N-(pyridin-3-ylmethyl)benzamide;hydrochloride
Molecular weight640.986
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogPNone
SynonymsLS-191023
Inchi KeyYDPSKBZTMQDVAD-WAQYZQTGSA-N
Inchi IDInChI=1S/C33H31Cl2N3O4.ClH/c1-5-37(19-21-7-6-14-36-18-21)31(39)22-9-12-28(35)26(15-22)33(2)27-16-24(34)10-13-29(27)38(32(33)40)20-23-8-11-25(41-3)17-30(23)42-4;/h6-18H,5,19-20H2,1-4H3;1H/t33-;/m0./s1
PubChem CID11549135
ChEMBLCHEMBL1253499
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID20550119ChEMBL

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