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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Cholecystokinin receptor type A
Species	Cavia porcellus (Guinea pig)
Gene	CCKAR
Synonym	CCK-A receptor CCK-AR CCK1-R Cholecystokinin-1 receptor
Disease	N/A for non-human GPCRs
Length	430
Amino acid sequence	MDVVDSLFVNGSNITSACELGFENETLFCLDRPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPSLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTGNMCRFLLPNDVMQQTWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFDAIQKKSAKERKTSTGSSGPMEDSDGCYLQKSRHPRKLELRQLSPSSSGSNRINRIRSSSSTANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAERHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGTPGVRGEMGEEEEGRTTGASLSRYSYSHMSTSAPPP
UniProt	Q63931
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3501
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Sonacon 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one CPD000058398 Tensium 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Desconet Tranquase A826456 Diapine Usempax ap Alupram Diazem Valrelease Antenex Diazepam Dak Vivol Assival Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material ZINC6427 BDBM50000766 Diazepam-Lipuro BRD-K16508793-001-01-8 Sedapam Calmociteno Setonil 439-14-5 Centrazepam NCGC00178168-04 Ducene Nivalen Eridan NSC-169897 Frustan Paralium HMS3393N04 Placidox 5 InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Q-pam Kratium 2 Relanium Liberetas Medipam Diazepin MLS000759402 Dizac CHEBI:49575 Spectrum5_001890 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one D00293 Tox21_113071_1 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Diaceplex Tranquo-tablinen AC-10561 Diastat (TN) Valiquid An-Ding Vatran Apaurin Diazepam Fabra WLN: T67 GNV JN IHJ CG G1 KR Azedipamin Diazepam [USAN:INN:BAN:JAN] Best [Pharaceutical] S.a. r.l. Diazepamu [Polish] BSPBio_003279 Seduxen 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one CAS-439-14-5 Sico Relax 53320-84-6 Nerozen Duxen Notense Evacalm NSC77518 Gihitan Paxate HSDB 3057 Pms-Diazepam KBio1_000967 Quetinil LA-111 Ro 5-2805 LS-122 Methyl diazepinone Dipam Morosan Drenian SMR000058398 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Chuansuan STK735517 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one DB00829 Trankinon 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Diapam UNII-Q3JTX2Q7TU Alboral Diatran Valium (TN) Ansiolin Diazepam 0.1 mg/ml in Methanol Velium Armonil Diazepam Nordic ZB000640 BCP23002 Diazepam, United States Pharmacopeia (USP) Reference Standard BIDD:GT0105 Saromet Calmaven Serenzin 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CCG-100997 DSSTox_RID_75566 Neurolytril EINECS 207-122-5 Novodipam Faustan, Paceum Gubex Placidox 10 Iazepam Prozepam Kiatrium Radizepam Lembrol Ruhsitus Mandrozep Diazepan Methyldiazepinone, pharmaceutical Disopam NCGC00178168-02 Cercine Spectrum3_001780 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine CS-0653 Tensopam 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Desloneg Tranquirit AAOVKJBEBIDNHE-UHFFFAOYSA-N Diaquel Valaxona Amiprol Diazemuls Valuzepam Anxicalm Diazepam Desitin W-5055 Atensine Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Zipan Bensedin Diazepam-ratiopharm Britazepam Sedipam (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Calmod Sibazon 5-24-04-00300 (Beilstein Handbook Reference) NCGC00260007-01 Duksen Nixtensyn Euphorin P NSC-77518 FT-0632135 Paranten HMS503A15 Plidan Jinpanfan Q-Pam Relanium LA 111 Reliver Lizan Mentalium Diazetard MLS001424086 Domalium Stesolid 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one D07JVL Tox21_202458 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Dialag Trazepam AC1L1EZE Diastat Acudial Valitran Anlin Diazepam (intranasal, epilepsy) Vazen Apo-diazepam Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Wy 3467 Baogin Diazepam [USAN:USP:INN:BAN:JAN] Betapam S.A.R.L. C-17931 Serenack 11100-37-1 Caudel Simasedan 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one DSSTox_CID_406 Nervium DZP Novazam Faustal Oprea1_126223 Gradual Paxel HY-17027 Pomin KBio3_002780 Quiatril La-Iii Ro 5-2807 Mandro Diazepamum Methyldiazepinone Dipaz NC00247 Solis 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Condition T-quil 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on DEA No. 2765 Tranqdyn A3662/0155188 Diapax Unisedil Aliseum Diazapam Valium R Ansiolisina Diazepam 1.0 mg/ml in Methanol Vival Arzepam Diazepam Rectubes Zepaxid BCP9000199 Diazepam-Eurogenerics BIDD:PXR0158 SCHEMBL21442 Calmocitene Servizepam CCRIS 6009 DTXSID4020406 NINDS_000967 Elcion CR NSC 169897 Freudal Pacitran HMS2051N04 Placidox 2 IDI1_000967 Psychopax Kratium Relaminal Levium MCULE-8990989144 Diazepan leo Metil Gobanal DivK1c_000967 NCGC00178168-03 Ceregulart Spectrum4_000576 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one D-Pam Tox21_113071 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Diacepan Tranquo-puren AB02310 Diastat Valeo AN-23449 Diazemulus Vanconin Anxionil Diazepam Elmu Winii Atilen Diazepam Stada Benzopin S.A. R.L Diazepamu BRN 0754371 Seduksen 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Calmpose Sibazone Nellium Dupin Noan Eurosan NSC169897 Gewacalm Parzam Horizon Plumiaz Kabivitrum Q3JTX2Q7TU LA III Renborin Lovium Metamidol Dienpax Mono (2-ethylhexyl) phthalate Doval 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one CHEMBL12 Stesolin 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one D0Y1YC Tranimul 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Dialar Umbrium AKOS003367969 Diastat, Valium Valium Ansilive Diazepam (JP17/USP/INN) Vazepam Apozepam Diazepam Intensol WY-3467 BCP0726000176 Diazepam, European Pharmacopoeia (EP) Reference Standard Bialzepam SAM001246536 C06948 Serenamin 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CC-26451 Sipam DSSTox_GSID_20406 neurolytr il e-Pam Novo-Dipam Faustan Ortopsique GTPL3364 Paxum I06-0194 Pro pam KBioGR_001012 Quievita Lamra Ro-52807 Mandro-Zep Diazepamum [INN-Latin] Methyldiazepinone (pharmaceutical) Dipezona NCGC00178168-01 [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<100000.0 nM	PMID2885419	BindingDB,ChEMBL

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