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GPCR

Name	Cholecystokinin receptor type A
Species	Cavia porcellus (Guinea pig)
Gene	CCKAR
Synonym	CCK-A receptor CCK-AR CCK1-R Cholecystokinin-1 receptor
Disease	N/A for non-human GPCRs
Length	430
Amino acid sequence	MDVVDSLFVNGSNITSACELGFENETLFCLDRPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPSLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTGNMCRFLLPNDVMQQTWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFDAIQKKSAKERKTSTGSSGPMEDSDGCYLQKSRHPRKLELRQLSPSSSGSNRINRIRSSSSTANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAERHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGTPGVRGEMGEEEEGRTTGASLSRYSYSHMSTSAPPP
UniProt	Q63931
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3501
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	diazepam
Molecular formula	C16H13ClN2O
IUPAC name	7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Molecular weight	284.743
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.0
Synonyms	Betapam C-17931 11100-37-1 Caudel 7 -chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one 7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one D07JVL 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one Dialag AC1L1EZE Diastat Acudial Anlin Diazepam (intranasal, epilepsy) Apo-diazepam Diazepam for system suitability, European Pharmacopoeia (EP) Reference Standard Baogin Diazepam [USAN:USP:INN:BAN:JAN] Tranimul Duxen Notense Umbrium Evacalm NSC77518 Valium Gihitan Paxate Vazepam HSDB 3057 Pms-Diazepam WY-3467 KBio1_000967 Quetinil LA-111 SAM001246536 Ro 5-2805 LS-122 Serenamin Methyl diazepinone Sipam Dipam Morosan Stesolin Drenian Nerozen Diazepam-Eurogenerics BIDD:PXR0158 Calmocitene CCRIS 6009 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Condition 7-chloro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2(3H)on DEA No. 2765 A3662/0155188 Diapax Aliseum Diazapam Ansiolisina Diazepam 1.0 mg/ml in Methanol Arzepam Diazepam Rectubes BCP9000199 Neurolytril Tranquase EINECS 207-122-5 Novodipam Usempax ap Faustan, Paceum Valrelease Gubex Placidox 10 Vivol Iazepam Prozepam ZINC6427 Kiatrium Radizepam Lembrol Sedapam Ruhsitus Mandrozep Setonil Diazepan Methyldiazepinone, pharmaceutical Sonacon Disopam NCGC00178168-02 Tensium DSSTox_RID_75566 Benzopin Diazepamu BRN 0754371 1-Methyl-5-phenyl-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Calmpose Ceregulart 7-Chloro-1-methyl-5-3H-1,4-benzodiazepin-2(1H)-one D-Pam 7-Chloro-1-methyl-5-phenyl-2-oxo-2,3-dihydro-1H-benzo[f]-1,4-diazepine Diacepan AB02310 Diastat AN-23449 Diazemulus Anxionil Diazepam Elmu Atilen Diazepam Stada Nixtensyn Tranquo-tablinen Euphorin P NSC-77518 Valiquid FT-0632135 Paranten Vatran HMS503A15 Plidan WLN: T67 GNV JN IHJ CG G1 KR Jinpanfan Q-Pam Relanium LA 111 S.a. r.l. Reliver Lizan Seduxen Mentalium Sico Relax Diazetard MLS001424086 Spectrum5_001890 Domalium NCGC00260007-01 Tox21_113071_1 Duksen Bialzepam C06948 2H-1, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CC-26451 7-chloranyl-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one CHEMBL12 7-chloro-1-methyl-5-phenyl-1,3-dihydro-[1,4]benzodiazepin-2-one D0Y1YC 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one Dialar AKOS003367969 Diastat, Valium Ansilive Diazepam (JP17/USP/INN) Apozepam Diazepam Intensol BCP0726000176 Diazepam, European Pharmacopoeia (EP) Reference Standard Trankinon DZP Novazam UNII-Q3JTX2Q7TU Faustal Oprea1_126223 Valium (TN) Gradual Paxel Velium HY-17027 Pomin ZB000640 KBio3_002780 Quiatril La-Iii Saromet Ro 5-2807 Mandro Serenzin Diazepamum Methyldiazepinone SMR000058398 Dipaz NC00247 STK735517 DSSTox_CID_406 Nervium Diazepam-Lipuro BRD-K16508793-001-01-8 Calmociteno 439-14-5 Centrazepam 7-chloro-1-methyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one CPD000058398 7-Chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Desconet A826456 Diapine Alupram Diazem Antenex Diazepam Dak Assival Diazepam solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material BDBM50000766 NINDS_000967 Tranquirit Elcion CR NSC 169897 Valaxona Freudal Pacitran Valuzepam HMS2051N04 Placidox 2 W-5055 IDI1_000967 Psychopax Zipan Kratium Relaminal Levium Sedipam MCULE-8990989144 Sibazon Diazepan leo Metil Gobanal Spectrum3_001780 DivK1c_000967 NCGC00178168-03 Tensopam DTXSID4020406 Best [Pharaceutical] Diazepamu [Polish] BSPBio_003279 1-Methyl-5-phenyl-7-chloro-1,4-benzodiazepin-2-one CAS-439-14-5 53320-84-6 CHEBI:49575 7-Chloro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one D00293 7-Chloro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one Diaceplex AC-10561 Diastat (TN) An-Ding Apaurin Diazepam Fabra Azedipamin Diazepam [USAN:INN:BAN:JAN] Dupin Noan Trazepam Eurosan NSC169897 Valitran Gewacalm Parzam Vazen Horizon Plumiaz Wy 3467 Kabivitrum Q3JTX2Q7TU LA III S.A.R.L. Renborin Lovium Serenack Metamidol Simasedan Dienpax Mono (2-ethylhexyl) phthalate Stesolid Doval Nellium Tox21_202458 Diazepam, United States Pharmacopeia (USP) Reference Standard BIDD:GT0105 Calmaven 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- CCG-100997 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H -1,4-benzodiazepin-2-one Chuansuan 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one DB00829 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one. Diapam Alboral Diatran Ansiolin Diazepam 0.1 mg/ml in Methanol Armonil Diazepam Nordic BCP23002 Tranqdyn e-Pam Novo-Dipam Unisedil Faustan Ortopsique Valium R GTPL3364 Paxum Vival I06-0194 Pro pam Zepaxid KBioGR_001012 Quievita Lamra SCHEMBL21442 Ro-52807 Mandro-Zep Servizepam Diazepamum [INN-Latin] Methyldiazepinone (pharmaceutical) Solis Dipezona NCGC00178168-01 T-quil DSSTox_GSID_20406 neurolytr il Diazepam-ratiopharm Britazepam (Z)-7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one Calmod 5-24-04-00300 (Beilstein Handbook Reference) Cercine 7-Chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepine CS-0653 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one Desloneg AAOVKJBEBIDNHE-UHFFFAOYSA-N Diaquel Amiprol Diazemuls Anxicalm Diazepam Desitin Atensine Diazepam solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis Bensedin Nivalen Tranquo-puren Eridan NSC-169897 Valeo Frustan Paralium Vanconin HMS3393N04 Placidox 5 Winii InChI=1/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H Q-pam Kratium 2 S.A. R.L Relanium Liberetas Seduksen Medipam Sibazone Diazepin MLS000759402 Spectrum4_000576 Dizac NCGC00178168-04 Tox21_113071 Ducene [ Show all ]
Inchi Key	AAOVKJBEBIDNHE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
PubChem CID	3016
ChEMBL	CHEMBL12
IUPHAR	3364
BindingDB	50000766
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<100000.0 nM	PMID2885419	BindingDB,ChEMBL

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