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Name | 5-hydroxytryptamine receptor 1D |
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Species | Mus musculus (Mouse) |
Gene | Htr1d |
Synonym | HTRL Htr1db HT1DA Gpcr14 5-HT-1D [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 374 |
Amino acid sequence | MSPPNQSLEGLPQEASNRSLNVTGAWDPEVLQALRISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVVHFRKIS |
UniProt | Q61224 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4297 |
IUPHAR | N/A |
DrugBank | N/A |
Name | Tonabersat |
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Molecular formula | C20H19ClFNO4 |
IUPAC name | N-[(3S,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3-chloro-4-fluorobenzamide |
Molecular weight | 391.823 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 2.9 |
Synonyms | SB-220453;SB 220453;SB220453 USL-260 5-HT1d agonist (migraine), Minster CHEMBL318191 MolPort-003-850-578 [ Show all ] |
Inchi Key | XLIIRNOPGJTBJD-ROUUACIJSA-N |
Inchi ID | InChI=1S/C20H19ClFNO4/c1-10(24)11-5-7-16-13(8-11)17(18(25)20(2,3)27-16)23-19(26)12-4-6-15(22)14(21)9-12/h4-9,17-18,25H,1-3H3,(H,23,26)/t17-,18-/m0/s1 |
PubChem CID | 6918324 |
ChEMBL | CHEMBL318191 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Increase | 143.0 % | PMID10021946 | ChEMBL |
Increase | 1192.0 % | PMID10021946 | ChEMBL |
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