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GPCR

NameG-protein coupled receptor homolog US28
SpeciesHuman cytomegalovirus (strain AD169) (HHV-5)
GeneUS28
SynonymHHRF3
DiseaseN/A for non-human GPCRs
Length354
Amino acid sequenceMTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProtP69332
Protein Data Bank4xt1
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4xt1.
BioLiPBL0309402,BL0309403
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4259
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL383822
Molecular formulaC28H32ClNO
IUPAC name4-(4-chlorophenyl)-1-[4-(3-methylphenyl)-4-phenylbutyl]piperidin-4-ol
Molecular weight434.02
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP6.5
Synonyms4-(4-Chloro-phenyl)-1-(4-phenyl-4-m-tolyl-butyl)-piperidin-4-ol
BDBM50027215
Inchi KeyXFNLYSXDMPXNNA-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H32ClNO/c1-22-7-5-10-24(21-22)27(23-8-3-2-4-9-23)11-6-18-30-19-16-28(31,17-20-30)25-12-14-26(29)15-13-25/h2-5,7-10,12-15,21,27,31H,6,11,16-20H2,1H3
PubChem CID11547305
ChEMBLCHEMBL383822
IUPHARN/A
BindingDB50027215
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5011500.0 nMPMID16190772BindingDB,ChEMBL

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