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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	Uridine 5'-diphosphate
Molecular formula	C9H14N2O12P2
IUPAC name	[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
Molecular weight	404.161
Hydrogen bond acceptor	12
Hydrogen bond donor	6
XlogP	-4.7
Synonyms	CHEBI:17659 FT-0601269 UNII-5G0F599A1Y Uridine 5'-pyrophosphate uridine-5'-diphosphate [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate 1o7o AC1Q1I4G BDBM50118239 CTK1G9536 Lopac0_001205 Uridine 5'-(trihydrogen diphosphate) (9CI) URIDINE DIPHOSPHATE URIDINE_DIPHOSPHATE C00015 DB03435 SCHEMBL4245 Uridine 5'-(trihydrogen pyrophosphate) (8CI) Uridine pyrophosphate (7CI) ZINC4490939 1gww 5G0F599A1Y AKOS028109013 FT-0615129 uridine 5''-(trihydrogen diphosphate) Uridine 5'-pyrophosphorate uridine-5-pyrophosphoric acid [({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid 2,4(1H,3H)-pyrimidinedione, 1-[5-O-[hydroxy(phosphonooxy)phosphinyl]-beta-D-ribofuranosyl]- BDBM50403871 D02HAL LS-160842 Uridine 5'-(trihydrogen diphosphate-P-32P) (9CI) Uridine diphosphate (6CI) V1660 ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate C9H14N2O12P2 EINECS 200-409-6 UDP Uridine, 5'-(trihydrogen diphosphate) [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphono hydrogen phosphate 1gx4 AC1L1LNF AN-41775 CHEMBL130266 GTPL1749 Uridine 5'-(trihydrogen diphosphate) Uridine 5'-pyrophosphoric acid uridine-diphosphate 5'-UDP bmse000266 DB-053298 NCGC00163324-01 Uridine 5'-(trihydrogen pyrophosphate) Uridine Pyrophosphate XCCTYIAWTASOJW-XVFCMESISA-N 58-98-0 [ Show all ]
Inchi Key	XCCTYIAWTASOJW-XVFCMESISA-N
Inchi ID	InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
PubChem CID	6031
ChEMBL	CHEMBL130266
IUPHAR	1749
BindingDB	50118239, 50403871
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	74.0 nM	PMID19759354	IUPHAR
EC50	160.0 nM	PMID20446735, PMID19902968	BindingDB,ChEMBL
EC50	160000.0 nM	PMID25868749	BindingDB,ChEMBL

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