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GPCR

Name	Alpha-2C adrenergic receptor
Species	Didelphis virginiana (North American opossum)
Gene	ADRA2C
Synonym	Alpha-2C adrenoceptor Alpha-2C adrenoreceptor Alpha-2CAR
Disease	N/A for non-human GPCRs
Length	469
Amino acid sequence	MDLQLTTNSTDSGDRGGSSNESLQRQPPSQYSPAEVAGLAAVVSFLIVFTIVGNVLVVIAVLTSRALKAPQNLFQVSLASADILVATLVMPFSLANELMNYWYFGKVWCVIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRIKGIIVTVWLISAVISFPPLISLYRDPEDDLYPQCELNDETWYILSSCIGSFFAPCIIMVLVYVRIYRVAKLRTRTLSEKRTVPEGSSQTENGLSRPPVGAGPSTAAAAAASLRLQAGENGHYHLHHHHHHLHHHHHHHHHQLRKSAELEDIELEESSTSENRRRRRSREEAAARKGSRGFSFSFSSTKGGQSAGAGSRLSRASNRSLEFFSTHRRRKRSSLCRRKVTQAREKRFTFVLAVVMGVFVVCWFPFFFTYSLYGICREACQVPETLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSFKHILFKKKKKTSLQ
UniProt	P35405
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	oxymetazoline
Molecular formula	C16H24N2O
IUPAC name	6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
Molecular weight	260.381
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	2.9
Synonyms	Oxymetazoline (INN) Rhinofrenol Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl- DSSTox_GSID_40691 Spectrum2_000998 Prestwick0_000224 Genasal Nasal Spray Up to 12 Hour Relief Tox21_110217_1 Iliadin ZINC57435 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol KBioSS_001531 8VLN5B44ZY Nasivine (Salt/Mix) Afrin Cherry 12 Hour Nasal Spray NCGC00015766-06 AK113123 NCGC00022345-02 BRD-K16195444-003-16-1 Operil (TN) CC-33432 Oxymetazolinum DivK1c_000567 SCH-9384 Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl- Duramist Plus Up To 12 Hour Nasal Decongestant Spray Spectrum5_001114 Prestwick3_000224 H-990 Vicks Sinex 12 Hour Nasal Spray 1491-59-4 KBio2_001531 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Lopac0_000903 AB00053513_14 NCGC00015766-01 Afrin Original 12 Hour Nose Drops NCGC00015766-09 BDBM30712 NCGC00022345-06 BSPBio_002145 Oximetazolinum D08322 Oxymetozoline Drixoral Nasal Solution SPBio_001095 Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-(7CI,8CI) FT-0601532 Tocris-1142 HSDB 3143 Visine L.R. 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol KBio3_001645 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol Nafrine AC1L1IM1 NCGC00015766-04 Afrin, Dristan12-hrnasalspray, Ocuclear, Drixine NCGC00015766-13 BPBio1_000419 NINDS_000567 CAS-1491-59-4 oxymetazolina oxymetazoline hydrochloride crystalline DB00935 Rhinolitan Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl- (9CI) DSSTox_RID_79545 Spectrum3_000533 Prestwick1_000224 GTPL124 UNII-8VLN5B44ZY KB-302508 6-tert-butyl-3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-2,4-dimethylphenol L000459 AB00053513-12 Navasin Afrin Extra Moisturizing 12 Hour Nasal Spray NCGC00015766-07 AKOS007930348 NCGC00022345-04 BRN 0886303 Oximetazolina CCG-204985 CHEMBL762 Oxymetazolinum [INN-Latin] Dristan Long Lasting Mentholated Nasal Spray SCHEMBL24301 Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl- EINECS 216-079-1 Spectrum_001051 Hazol Vicks Sinex 12 Hour Ultra Fine Mist for Sinus Relief 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline KBio2_004099 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol LS-104146 AB00053513_15 NCGC00015766-02 Afrin Original 12 Hour Pump Mist NCGC00015766-10 Biomol-NT_000161 Neo-Synephrine 12 Hour Spray C-16261 Oxylazine D09EBS Phenol, 3-((4,5-dihydro-1H-imidazol-2-yl)methyl)-6-(1,1-dimethylethyl)-2,4-dimethyl- DSSTox_CID_20691 SPBio_002188 Phenol,3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl- FT-0650596 Tox21_110217 IDI1_000567 WYWIFABBXFUGLM-UHFFFAOYSA-N KBioGR_000908 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol # Nasal Relief 12 Hour Nasal Spray Afrin NCGC00015766-05 AJ-09693 NCGC00015766-16 BRD-K16195444-001-01-7 Nostrilla 12 Hour Nasal Decongestant CAS-151615 Oxymetazoline [INN:BAN] Decongestant (TN) SBI-0050878.P004 Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-(9CI) DTXSID3040691 Spectrum4_000464 Prestwick2_000224 H 990 Vicks Sinex KBio1_000567 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenol;hydrochloride Lopac-O-2378 AB00053513-13 Navisin Afrin Original 12 Hour Nasal Spray NCGC00015766-08 AN-10265 NCGC00022345-05 BSPBio_000267 Oximetazolina [INN-Spanish] CHEBI:7862 cid_66259 Oxymethazoline Dristan Long Lasting Nasal Mist Sinerol Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl- (7CI,8CI) FT-0082560 STK075254 HMS2089G03 Visine L.R 3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-6-tert-butyl-phenol KBio2_006667 6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-phenol;hydrochloride MCULE-8690625159 AC-6370 NCGC00015766-03 Afrin Sinus 12 Hour Nasal Spray NCGC00015766-11 BPBio1_000295 Nezeril C07363 oxymeta zoline [ Show all ]
Inchi Key	WYWIFABBXFUGLM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)
PubChem CID	4636
ChEMBL	CHEMBL762
IUPHAR	124
BindingDB	30712
DrugBank	DB00935
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	73.0 nM	PMID1656026	BindingDB

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