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GLASS

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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	procyclidine
Molecular formula	C19H29NO
IUPAC name	1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
Molecular weight	287.447
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	DivK1c_000429 KBio2_001342 L001290 NSC-169103 Prociclidina [INN-Spanish] Procyclidinum [INN-Latin] 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol Spectrum2_001298 77-37-2 Tricyclamol Arpicolin C07378 Elorine KBio3_001733 Metanin Prestwick0_000844 Procyclidin .alpha.-Cyclohexyl-.alpha.-phenyl-1-pyrrolidinepropanol SBI-0051493.P003 1-PYRROLIDINEPROPANOL, alpha-CYCLOHEXYL-alpha-PHENYL- Spectrum5_001224 AB00053533_16 WYDUSKDSKCASEF-UHFFFAOYSA-N BRD-A31800922-003-05-3 CHEMBL86715 IDI1_000429 Kemadrin NINDS_000429 Prestwick3_000844 Procyclidine [INN:BAN] 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol SPBio_001335 Triciloid AC1Q77DP BSPBio_000827 DTXSID2023515 KBio2_003910 Lergine NSC169103 Procidlidina Procyklidin 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Spectrum3_000557 AB00053533 Vagosin BDBM50062598 CHEBI:8448 GTPL7280 KBioGR_000977 NCGC00018186-02 Prestwick1_000844 1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol SCHEMBL147344 107661-03-0 Spectrum_000862 AC1L1J8M BRD-A31800922-003-15-2 D08425 DB00387 KBio1_000429 Kemadrine NSC 169103 Prociclidina Procyclidinum 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride SPBio_002748 56172-67-9 Tricoloid API0008986 BSPBio_002233 EINECS 201-023-0 KBio2_006478 LS-138139 Osnervan Procyclid Prosyklidin 1-Pyrrolidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl- Spectrum4_000489 AB00053533_15 WLN: T5NTJ A2XQR&- AL6TJ BPBio1_000911 HSDB 7678 KBioSS_001342 NCGC00018186-04 Prestwick2_000844 Procyclidine (INN) 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol Spamol 5-20-01-00250 (Beilstein Handbook Reference) Triciclidina AC1Q76Z5 BRN 0088563 D0R1WR [ Show all ]
Inchi Key	WYDUSKDSKCASEF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
PubChem CID	4919
ChEMBL	CHEMBL86715
IUPHAR	N/A
BindingDB	50062598
DrugBank	DB00387
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.47 nM	PMID2250662	BindingDB

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