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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2037456
Molecular formula	C7H2Br2O3S2
IUPAC name	5,6-dibromo-3-hydroxythieno[3,2-b]thiophene-2-carboxylic acid
Molecular weight	358.018
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.5
Synonyms	BDBM50385230
Inchi Key	CCFHQQFXVCRZQD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H2Br2O3S2/c8-1-3-4(14-6(1)9)2(10)5(13-3)7(11)12/h10H,(H,11,12)
PubChem CID	66561717
ChEMBL	CHEMBL2037456
IUPHAR	N/A
BindingDB	50385230
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	16.0 nM	PMID22572579	BindingDB,ChEMBL
EC50	2460.0 nM	PMID22572579	BindingDB,ChEMBL
Efficacy	96.0 %	PMID22572579	ChEMBL
Efficacy	228.0 %	PMID22572579	ChEMBL

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