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Name | Glucagon receptor |
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Species | Homo sapiens (Human) |
Gene | GCGR |
Synonym | GL-R GGR GR glucagon receptor |
Disease | Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes [ Show all ] |
Length | 477 |
Amino acid sequence | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF |
UniProt | P47871 |
Protein Data Bank | 5yqz, 5xez, 5ee7, 5xf1 |
GPCR-HGmod model | P47871 |
3D structure model | This structure is from PDB ID 5yqz. |
BioLiP | BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437 |
Therapeutic Target Database | T60182, T87875 |
ChEMBL | CHEMBL1985 |
IUPHAR | 251 |
DrugBank | N/A |
Name | CHEMBL1933352 |
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Molecular formula | C24H27N3O4 |
IUPAC name | 3-[[4-[1-[1-(3-methylphenyl)pyrazol-4-yl]oxybutyl]benzoyl]amino]propanoic acid |
Molecular weight | 421.497 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 3.8 |
Synonyms | BDBM50360586 |
Inchi Key | AESZMKKULCOPFY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H27N3O4/c1-3-5-22(18-8-10-19(11-9-18)24(30)25-13-12-23(28)29)31-21-15-26-27(16-21)20-7-4-6-17(2)14-20/h4,6-11,14-16,22H,3,5,12-13H2,1-2H3,(H,25,30)(H,28,29) |
PubChem CID | 57402151 |
ChEMBL | CHEMBL1933352 |
IUPHAR | N/A |
BindingDB | 50360586 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kb | <20900.0 nM | PMID22119466 | ChEMBL |
Ki | 1110.0 nM | PMID22119466 | BindingDB,ChEMBL |
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