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GPCR

NameSomatostatin receptor type 4
SpeciesMus musculus (Mouse)
GeneSstr4
SynonymSRIF2B
SS-4-R
SS4-R
SS4R
SST4 receptor
DiseaseN/A for non-human GPCRs
Length385
Amino acid sequenceMNAPATLPPGVEDTTWTPGINASWAPDEEEEDAMGSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFARSAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLATATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLPPVLAIGLCYLLIVGKMRAVALAGGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGAGCICPPLPCQQEPVQAEPGCKQVPFTKTTTF
UniProtP49660
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4397
IUPHAR358
DrugBankN/A

Ligand

NameCHEMBL2069502
Molecular formulaC25H26N4O
IUPAC name(1R,3R)-1-(oxan-4-yl)-3-(5-phenyl-1H-imidazol-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Molecular weight398.51
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP3.5
SynonymsBDBM50389590
Inchi KeyWTEHMPUGVAOZBF-FYYLOGMGSA-N
Inchi IDInChI=1S/C25H26N4O/c1-2-6-16(7-3-1)22-15-26-25(29-22)21-14-19-18-8-4-5-9-20(18)27-24(19)23(28-21)17-10-12-30-13-11-17/h1-9,15,17,21,23,27-28H,10-14H2,(H,26,29)/t21-,23-/m1/s1
PubChem CID57384077
ChEMBLCHEMBL2069502
IUPHARN/A
BindingDB50389590
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<10000.0 nMPMID24900466BindingDB,ChEMBL

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