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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	Mozavaptan
Molecular formula	C27H29N3O2
IUPAC name	N-[4-[5-(dimethylamino)-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide
Molecular weight	427.548
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.5
Synonyms	AC1L3OOQ C27H29N3O2 D0IW7O GTPL2197 N-[4-[5-(dimethylamino)-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methylbenzamide Q-101868 5-(Dimethylamino)-1-[4-(2-methylbenzamido)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine AN-12174 DSSTox_RID_97316 KB-55102 N-(4-((5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)phenyl)-2-methylbenzamide NCGC00262931-01 SB18801 A807320 BDBM35714 CS-6286 EX-A1127 LS-26673 N-[4-(5-dimethylamino2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide Opc-31260 VA11331 4CA-0941 AK326129 CAS-137975-06-5 DSSTox_CID_31430 HY-18346 Mozavaptan [INN] N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1-benzazepin-1-yl]-oxomethyl]phenyl]-2-methylbenzamide RL01669 5-Dimethylamino-1-(4-(2-methylbenzoylamino)benzoyl)-2,3,4,5-tetrahydro-1H-benzazepine AS-35085 CHEMBL420762 DTXSID8057641 KS-00000XI4 N-(4-(5-(dimethylamino)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide NCGC00262931-02 SCHEMBL1649322 2563AH AC-4255 Benzamide, N-(4-((5-(dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)phenyl)-2-methyl- D0F4NS FT-0652996 MolPort-019-991-660 N-[4-[5-(dimethylamino)-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]phenyl]-2-methyl-benzamide OPC31260 5-(dimethylamino)-1-(4-(2-methylbenzamido)benzoyl)-2,3,4,5-tetrahydro-1h-benzazepine AKOS015895761 CHEBI:135694 DSSTox_GSID_57641 I06-1501 N-(4-(((5RS)-5-(Dimethylamino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)phenyl)-2-methylbenzamide N-[4-[[5-(dimethylamino)-2,3,4,5-tetrahydro-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-benzamide s2920 137975-06-5 975M065 BCP06718 CM0159 EBD17887 L001435 N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide Opc 31260 Tox21_113926 [ Show all ]
Inchi Key	WRNXUQJJCIZICJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)
PubChem CID	119369
ChEMBL	CHEMBL420762
IUPHAR	2197
BindingDB	35714
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	12.0 nM	PMID8784453	BindingDB,ChEMBL
IC50	300.0 nM	PMID7241506	BindingDB,ChEMBL
Ki	6.1 nM	PMID9223568	BindingDB
Ki	6.30957 - 39.8107 nM	PMID9864265, PMID9792651	IUPHAR
Ki	6.36 nM	PMID9864265	BindingDB
Ki	42.3 nM	PMID9223568	BindingDB

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