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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 6
Species	Homo sapiens (Human)
Gene	LPAR6
Synonym	Purinergic receptor 5 P2Y5 P2Y purinoceptor 5 P2RY5 oleoyl-L-alpha-lysophosphatidic acid receptor LPA6 receptor LPA-6 LPA receptor 6 RB intron encoded G-protein coupled receptor [ Show all ]
Disease	N/A
Length	344
Amino acid sequence	MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMINLAMSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQGNNASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKPVTLSRSKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLKSKIFDNESAA
UniProt	P43657
Protein Data Bank	N/A
GPCR-HGmod model	P43657
3D structure model	This predicted structure model is from GPCR-EXP P43657.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2331058
IUPHAR	163
DrugBank	N/A

Ligand

Name	1-Oleoyl Lysophosphatidic Acid
Molecular formula	C21H41O7P
IUPAC name	[(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-octadec-9-enoate
Molecular weight	436.526
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.2
Synonyms	Epitope ID:158640 LPA(18:1/0:0) Lysophosphatidic acid(18:1/0:0) NKP ZINC8860530 1-O-oleyl-sn-glycerol 3-phosphate 1-oleyl-sn-glycerol 3-phosphate 9-Octadecenoic acid (Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester, (R)- HMS3650F05 LysoPA(18:1(9Z)/0:0) MolPort-009-019-282 SCHEMBL1560791 (2R)-2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate 1-Oleoyl-L-.alpha.-lysophosphatidic acid 1293AH BSPBio_001406 LPA 18:1 lysophosphatidic acid NCGC00161386-02 UNII-PG6M3969SG component WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid 1-oleoylglycerol 3-phosphate 65528-98-5 HMS1791G08 LPA(18:1n9/0:0) Lysophosphatidic acid(18:1n9/0:0) PA(18:1(9Z)/0:0) [(2R)-2-hydroxy-3-phosphonooxypropyl] (Z)-octadec-9-enoate 1-oleylglycerol 3-phosphate AC1NSKBQ C21H41O7P IDI1_033876 LysoPA(18:1) Monooleylphosphatidic acid SR-01000946335 (R)-Octadec-9-enoic acid 2-hydroxy-3-phosphonooxy-propyl ester 1-Oleoyl-sn-glycero-3-phosphate 18:1 LPA CHEMBL117021 LPA(18:1(9Z)/0:0) Lysophosphatidic acid(18:1) NCGC00161386-03 WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-O-oleoyl-sn-glycerol 3-phosphate 1-oleyl-2-lyso-sn-glycerol 3-phosphatidic acid 9-Octadecenoic acid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester HMS1989G08 LPA(18:1w9/0:0) Lysophosphatidic acid(18:1w9/0:0) PA(18:1/0:0) (2r)-2-Hydroxy-3-(Phosphonooxy)propyl (9e)-Octadec-9-Enoate 1-oleoyl-2-lyso-sn-glycerol 3-phosphatidic acid 1-Oleyllysophosphatidic acid BDBM50148348 CHEBI:62837 LMGP10050008 LysoPA(18:1w9/0:0) NCGC00161386-01 SR-01000946335-1 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate 1-Oleoyl-sn-glycerol 3-phosphate [ Show all ]
Inchi Key	WRGQSWVCFNIUNZ-GDCKJWNLSA-N
Inchi ID	InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-/t20-/m1/s1
PubChem CID	5311263
ChEMBL	CHEMBL117021
IUPHAR	N/A
BindingDB	50148348
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	970.0 nM	PMID23395664	BindingDB,ChEMBL
EC50	977.24 nM	PMID23395664	ChEMBL
Intrinsic activity	1.0 -	PMID23395664	ChEMBL

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