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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	F1243-0137
Molecular formula	C17H20ClNO3
IUPAC name	1-(1-chloronaphthalen-2-yl)oxy-3-morpholin-4-ylpropan-2-ol
Molecular weight	321.801
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.8
Synonyms	Propan-2-ol, 1-(1-chloronaphthalen-2-yloxy)-3-morpholin-4-yl- A2905/0122425 EU-0048344 MCULE-6562341418 STK723948 1-(1-Chloro-naphthalen-2-yloxy)-3-morpholin-4-yl-propan-2-ol AKOS000602967 Oprea1_329417 1-[(1-chloronaphthalen-2-yl)oxy]-3-(morpholin-4-yl)propan-2-ol SMR000013133 AAOASDWEYNETMY-UHFFFAOYSA-N MLS000035056 1-(1-chloronaphthalen-2-yl)oxy-3-morpholin-4-ylpropan-2-ol AKOS016402421 Oprea1_641000 3-(1-chloro(2-naphthyloxy))-1-morpholin-4-ylpropan-2-ol CHEMBL1506291 ST4076297 1-((1-chloronaphthalen-2-yl)oxy)-3-morpholinopropan-2-ol AC1LDAVC HMS2338O17 MolPort-000-682-526 1-[(1-chloro-2-naphthyl)oxy]-3-morpholino-2-propanol BAS 04999543 [ Show all ]
Inchi Key	AAOASDWEYNETMY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H20ClNO3/c18-17-15-4-2-1-3-13(15)5-6-16(17)22-12-14(20)11-19-7-9-21-10-8-19/h1-6,14,20H,7-12H2
PubChem CID	645174
ChEMBL	CHEMBL1506291
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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