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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	MLS-0203836.0001
Molecular formula	C27H22N4O3S2
IUPAC name	2-(2,4-dimethylphenyl)-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide
Molecular weight	514.618
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	5.3
Synonyms	2-(2,4-dimethylphenyl)-N-{4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}-4-quinolinecarboxamide HMS2539B20 ST50914578 AKOS003253291 MLS-0203836.0002 [2-(2,4-dimethylphenyl)(4-quinolyl)]-N-{4-[(1,3-thiazol-2-ylamino)sulfonyl]phe nyl}carboxamide 2-(2,4-dimethylphenyl)-N-[4-(thiazol-2-ylsulfamoyl)phenyl]cinchoninamide CHEMBL1382214 MolPort-001-490-447 MCULE-4327256132 STK439388 2-(2,4-dimethylphenyl)-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide BDBM76075 MLS000579675 2-(2,4-dimethylphenyl)-N-[4-(thiazol-2-ylsulfamoyl)phenyl]quinoline-4-carboxamide cid_1358622 SMR000186863 AC1LQXBV ZINC1200294 2-(2,4-dimethylphenyl)-N-[4-(2-thiazolylsulfamoyl)phenyl]-4-quinolinecarboxamide MLS003904724 [ Show all ]
Inchi Key	BZRLSZPXWKJEHX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H22N4O3S2/c1-17-7-12-21(18(2)15-17)25-16-23(22-5-3-4-6-24(22)30-25)26(32)29-19-8-10-20(11-9-19)36(33,34)31-27-28-13-14-35-27/h3-16H,1-2H3,(H,28,31)(H,29,32)
PubChem CID	1358622
ChEMBL	CHEMBL1382214
IUPHAR	N/A
BindingDB	76075
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<32000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
IC50	<32000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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