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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	SMR000005572
Molecular formula	C21H23N3O4S
IUPAC name	N-cyclopentyl-4-methoxy-N-[(4-oxo-3H-quinazolin-2-yl)methyl]benzenesulfonamide
Molecular weight	413.492
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.8
Synonyms	MLS000027187 ASN 05813046 N-cyclopentyl-4-methoxy-N-[(4-oxo-1H-quinazolin-2-yl)methyl]benzenesulfonamide SR-01000332890-1 HMS2324G21 AC1LCSEV MLS002537989 ZINC8582802 MCULE-2853117719 AKOS000762654 N-Cyclopentyl-4-methoxy-N-(4-oxo-3,4-dihydro-quinazolin-2-ylmethyl)-benzenesulfonamide CHEMBL1389594 SR-01000332890 [ Show all ]
Inchi Key	AANUXMLLBCNNNU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H23N3O4S/c1-28-16-10-12-17(13-11-16)29(26,27)24(15-6-2-3-7-15)14-20-22-19-9-5-4-8-18(19)21(25)23-20/h4-5,8-13,15H,2-3,6-7,14H2,1H3,(H,22,23,25)
PubChem CID	135417679
ChEMBL	CHEMBL1389594
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	11220.2 nM	PubChem BioAssay data set	ChEMBL

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