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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Mus musculus (Mouse)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P12657
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3733
IUPHAR	13
DrugBank	N/A

Ligand

Name	Oxotremorine M
Molecular formula	C11H19IN2O
IUPAC name	trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium;iodide
Molecular weight	322.19
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	None
Synonyms	CCG-222258 HMS3262P10 N,N,N,-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide oxotremorine M iodide Tox21_500954 63939-65-1 CTK8G2226 HMS501C21 NCGC00094256-01 Oxotremorine-M iodide AOB4621 FCH2296542 MLS000859927 O-100 SR-01000075338-1 trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium iodide 2-Butyn-1-aminium, 4-(2-oxo-1-pyrrolidinyl)-N,N,N-trimethyl-, iodide HMS3267E18 N,N,N-Trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide Oxotremorine M, solid AC1MHKBB ER95520000 LP00954 NCGC00261639-01 SMR000326788 BN0401 HMS2233F17 MolPort-003-983-655 SR-01000075338-3 4-(2-Oxo-1-pyrrolidinyl)-N,N,N-trimethyl-2-butyn-1-aminium iodide CHEMBL23957 HMS3372B22 N,N,N-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide oxotremorine methiodide AKOS024456364 EU-0100954 LS-47470 NIOSH/ER9552000 SR-01000075338 [ Show all ]
Inchi Key	VVLMSCJCXMBGDI-UHFFFAOYSA-M
Inchi ID	InChI=1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1
PubChem CID	3027782
ChEMBL	CHEMBL23957
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	700.0 nM	PMID9111297	ChEMBL
Smax	380.0 %	PMID9111297	ChEMBL

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