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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	AC1OJ1IV
Molecular formula	C19H23N5
IUPAC name	5-methyl-3-(prop-2-enylamino)-6-[(2,4,6-trimethylanilino)methyl]pyrazine-2-carbonitrile
Molecular weight	321.428
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.4
Synonyms	HMS2836O08 3-(allylamino)-6-[(mesitylamino)methyl]-5-methyl-2-pyrazinecarbonitrile SMR000477880 MLS001178355 5-methyl-3-(prop-2-enylamino)-6-[(2,4,6-trimethylanilino)methyl]pyrazine-2-carbonitrile ZINC4661759 CHEMBL1587946 3-(Allylamino)-5-methyl-6-[[(2,4,6-trimethylphenyl)amino]methyl]-2-pyrazinecarbonitrile MolPort-003-823-555 [ Show all ]
Inchi Key	AANRDBZIXJEKER-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H23N5/c1-6-7-21-19-16(10-20)24-17(15(5)23-19)11-22-18-13(3)8-12(2)9-14(18)4/h6,8-9,22H,1,7,11H2,2-5H3,(H,21,23)
PubChem CID	7312626
ChEMBL	CHEMBL1587946
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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