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GPCR

NameG-protein coupled receptor homolog US28
SpeciesHuman cytomegalovirus (strain AD169) (HHV-5)
GeneUS28
SynonymHHRF3
DiseaseN/A for non-human GPCRs
Length354
Amino acid sequenceMTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProtP69332
Protein Data Bank4xt1
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4xt1.
BioLiPBL0309402,BL0309403
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4259
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL198332
Molecular formulaC27H28Cl3NO
IUPAC name4-(4-chlorophenyl)-1-[4-(3,4-dichlorophenyl)-4-phenylbutyl]piperidin-4-ol
Molecular weight488.877
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP7.4
SynonymsBDBM50027202
4-(4-Chloro-phenyl)-1-[4-(3,4-dichloro-phenyl)-4-phenyl-butyl]-piperidin-4-ol
Inchi KeyVDRWTCGLKKUENO-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H28Cl3NO/c28-23-11-9-22(10-12-23)27(32)14-17-31(18-15-27)16-4-7-24(20-5-2-1-3-6-20)21-8-13-25(29)26(30)19-21/h1-3,5-6,8-13,19,24,32H,4,7,14-18H2
PubChem CID11569984
ChEMBLCHEMBL198332
IUPHARN/A
BindingDB50027202
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5015800.0 nMPMID16190772BindingDB,ChEMBL

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