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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	3,5-DIHYDROXYBENZOIC ACID
Molecular formula	C7H6O4
IUPAC name	3,5-dihydroxybenzoic acid
Molecular weight	154.121
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	0.9
Synonyms	alpha-Resorcylic acid Benzoic acid, 3,5-dihydroxy- D0W1OR HY-W015560 MCULE-4631439955 PubChem9162 ST50824444 Z1705787110 4-10-00-01501 (Beilstein Handbook Reference) AC-1166 ANW-13674 DTXSID8059184 InChI=1/C7H6O4/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,8-9H,(H,10,11 NE10203 RTC-020130 2WC5LMO6L1 TC-020130 3,5-Dihydroxybenzoic acid, 97% AE-562/40806860 AK-44160 BC676294 CTK3I9682 FT-0602267 KSC489M8F NSC22948 SCHEMBL28106 3,5-Dihydroxy-benzoic acid UNII-2WC5LMO6L1 3,5-dihyroxybenzoic acid AB00234 alpha-Resorcylic Acid (3,5-Dihydroxybenzoic Acid) BRN 2207864 D2554 I01-0441 MFCD00002512 Q-200348 STL146349 3,5-Dihydroxybenzoic acid (ACD/Name 4.0) ZINC388546 5-Carboxyresorcinol AC1L1OQD AI3-52338 B7686 CHEMBL95308 EINECS 202-730-7 KB-28723 NSC 22948 SBB058836 3,5-DHBA TL8006060 3,5-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 97% 99-10-5 AKOS005721135 BDBM50336490 D0570 GTPL5783 LS-143431 PS-4051 ST2410308 3,5-Dihydroxybenzoate, IX UYEMGAFJOZZIFP-UHFFFAOYSA-N 34D AC-10253 AN-15192 CHEBI:39912 DB-028292 I01-5235 MolPort-001-759-970 RP21800 .alpha.-Resorcylic acid STR02341 3,5-dihydroxybenzoic acid (alpha-resorcylic acid) ACMC-1BQHO AJ-20678 BBL019762 CS-W016276 F0001-2331 KS-00000074 NSC-22948 SC-07533 3,5-Dihydroxy benzoic acid TRA0063493 3,5-Dihydroxybenzoicacid a-resorcylic acid [ Show all ]
Inchi Key	UYEMGAFJOZZIFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H6O4/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,8-9H,(H,10,11)
PubChem CID	7424
ChEMBL	CHEMBL95308
IUPHAR	5783
BindingDB	50336490
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID24900524	BindingDB,ChEMBL

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