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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Hydroxycarboxylic acid receptor 1
Species	Homo sapiens (Human)
Gene	HCAR1
Synonym	lactate receptor 1 LACR1 HCA1 receptor Gpr81 G-protein coupled receptor 81 G-protein coupled receptor 104 G protein-coupled receptor 81 G protein-coupled receptor 104 FKSG80 T-cell activation G protein-coupled receptor [ Show all ]
Disease	N/A
Length	346
Amino acid sequence	MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
UniProt	Q9BXC0
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXC0
3D structure model	This predicted structure model is from GPCR-EXP Q9BXC0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075101
IUPHAR	311
DrugBank	N/A

Ligand

Name	3,5-DIHYDROXYBENZOIC ACID
Molecular formula	C7H6O4
IUPAC name	3,5-dihydroxybenzoic acid
Molecular weight	154.121
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	0.9
Synonyms	5-Carboxyresorcinol AC1L1OQD alpha-Resorcylic Acid (3,5-Dihydroxybenzoic Acid) BRN 2207864 D2554 I01-0441 MFCD00002512 Q-200348 STL146349 3,5-Dihydroxybenzoic acid (ACD/Name 4.0) ZINC388546 99-10-5 AI3-52338 B7686 CHEMBL95308 EINECS 202-730-7 KB-28723 NSC 22948 SBB058836 3,5-DHBA TL8006060 3,5-Dihydroxybenzoic acid, Vetec(TM) reagent grade, 97% 34D AC-10253 AKOS005721135 BDBM50336490 D0570 GTPL5783 LS-143431 PS-4051 ST2410308 3,5-Dihydroxybenzoate, IX UYEMGAFJOZZIFP-UHFFFAOYSA-N ACMC-1BQHO AN-15192 CHEBI:39912 DB-028292 I01-5235 MolPort-001-759-970 RP21800 .alpha.-Resorcylic acid STR02341 3,5-dihydroxybenzoic acid (alpha-resorcylic acid) a-resorcylic acid AJ-20678 BBL019762 CS-W016276 F0001-2331 KS-00000074 NSC-22948 SC-07533 3,5-Dihydroxy benzoic acid TRA0063493 3,5-Dihydroxybenzoicacid 4-10-00-01501 (Beilstein Handbook Reference) AC-1166 alpha-Resorcylic acid Benzoic acid, 3,5-dihydroxy- D0W1OR HY-W015560 MCULE-4631439955 PubChem9162 ST50824444 Z1705787110 AE-562/40806860 ANW-13674 DTXSID8059184 InChI=1/C7H6O4/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,8-9H,(H,10,11 NE10203 RTC-020130 2WC5LMO6L1 TC-020130 3,5-Dihydroxybenzoic acid, 97% AB00234 AK-44160 BC676294 CTK3I9682 FT-0602267 KSC489M8F NSC22948 SCHEMBL28106 3,5-Dihydroxy-benzoic acid UNII-2WC5LMO6L1 3,5-dihyroxybenzoic acid [ Show all ]
Inchi Key	UYEMGAFJOZZIFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H6O4/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,8-9H,(H,10,11)
PubChem CID	7424
ChEMBL	CHEMBL95308
IUPHAR	5783
BindingDB	50336490
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	191000.0 nM	PMID22434674	IUPHAR
EC50	377000.0 nM	PMID24900524	BindingDB,ChEMBL

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