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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 1
Species	Homo sapiens (Human)
Gene	LPAR1
Synonym	lysophosphatidic acid receptor Edg-2 Lpar1 LPA1 receptor Lysophosphatidic acid receptor Edg-2 {ECO:0000303\|PubMed:9070858} LPA-1 LPA receptor 1 GPR26 endothelial differentiation gene 2, lysophosphatidic acid G-protein-coupled receptor, 2 EDG2 VZG1 [ Show all ]
Disease	Idiopathic pulmonary fibrosis
Length	364
Amino acid sequence	MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProt	Q92633
Protein Data Bank	4z36, 4z35, 4z34
GPCR-HGmod model	Q92633
3D structure model	This structure is from PDB ID 4z36.
BioLiP	BL0315557, BL0315553, BL0315554, BL0315555, BL0315556, BL0315558
Therapeutic Target Database	T92640
ChEMBL	CHEMBL3819
IUPHAR	272
DrugBank	N/A

Ligand

Name	Tetradecylphosphonic acid
Molecular formula	C14H31O3P
IUPAC name	tetradecylphosphonic acid
Molecular weight	278.373
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.1
Synonyms	1-Tetradecylphosphonic Acid BBL103226 CTK3J7960 I14-8487 Phosphonic acid, P-tetradecyl- Tetradecyl phosphonic acid 4671-75-4 BVQJQTMSTANITJ-UHFFFAOYSA-N DTXSID7063550 MolPort-006-116-374 SCHEMBL19906 WLN: QPQO&14 ACM4671754 FT-0693992 NSC127409 STL557036 1956AH BDBM50170846 D0P7GR LS-106793 Phosphonic acid, tetradecyl- Tetradecyl-phosphonic acid Tetradecylphosphonic acid, 97% C-52694 EINECS 225-118-1 n-Tetradecylphosphonic acid SR-01000946789 ZINC36178975 1-Tetradecanephosphonic acid AKOS015918250 CHEMBL190999 HMS3650I03 P-tetradecyl-Phosphonic acid Tetradecanephosphonic acid 4-04-00-03566 (Beilstein Handbook Reference) BRN 1784271 DB-070750 MFCD00015834 RT-004112 tetradecylphosphonate Tetradecylphosphonic acid, 99+ % AC1L2V5G C14H31O3P F0001-1259 NSC-127409 SR-01000946789-1 [ Show all ]
Inchi Key	BVQJQTMSTANITJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H31O3P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18(15,16)17/h2-14H2,1H3,(H2,15,16,17)
PubChem CID	78401
ChEMBL	CHEMBL190999
IUPHAR	N/A
BindingDB	50170846
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	10000.0 nM	PMID16033271	ChEMBL

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