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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Succinate receptor 1
Species	Homo sapiens (Human)
Gene	SUCNR1
Synonym	succinate receptor 1 succinate receptor P2Y purinoceptor 1-like P2Y purinoceptor 1 GPR91 G-protein coupled receptor 91 G protein-coupled receptor 91 SUCNR1 [ Show all ]
Disease	N/A
Length	334
Amino acid sequence	MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
UniProt	Q9BXA5
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXA5
3D structure model	This predicted structure model is from GPCR-EXP Q9BXA5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2150838
IUPHAR	166
DrugBank	BE0002258

Ligand

Name	CHEMBL2153469
Molecular formula	C24H19F4N5O
IUPAC name	N-[[2-[4-fluoro-3-(trifluoromethyl)phenyl]pyrimidin-5-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide
Molecular weight	469.444
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	3.8
Synonyms	BDBM50393137
Inchi Key	UHJPHULYDYNQMT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H19F4N5O/c25-20-9-7-17(11-19(20)24(26,27)28)22-31-13-15(14-32-22)12-30-21(34)5-1-4-18-8-6-16-3-2-10-29-23(16)33-18/h2-3,6-11,13-14H,1,4-5,12H2,(H,30,34)
PubChem CID	71462033
ChEMBL	CHEMBL2153469
IUPHAR	N/A
BindingDB	50393137
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	49.0 nM	PMID21571530	BindingDB,ChEMBL

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