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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 1F
Species	Mus musculus (Mouse)
Gene	Htr1f
Synonym	HTR1EL 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 5-HT6 5-HT1F receptor 5-HT1F 5-HT1Ebeta 5-HT-1F 5-HT-1E-beta serotonin receptor 1F [ Show all ]
Disease	N/A for non-human GPCRs
Length	366
Amino acid sequence	MDFLNASDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVEYARKRTPRHAGIMITIVWVISVFISMPPLFWRHQGTSRDDECVIKHDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLYHKRQASRMIKEELNGQVFLESGEKSIKLVSTSYMLEKSLSDPSTDFDRIHSTVKSPRSELKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRY
UniProt	Q02284
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	5
DrugBank	N/A

Ligand

Name	(S)-mianserin
Molecular formula	C18H20N2
IUPAC name	(7S)-5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene
Molecular weight	264.372
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.4
Synonyms	Mianserin, (S)- AC1L4C1L SCHEMBL353397 (S)-1,2,3.4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine CHEMBL252719 MIANSERIN (+) UNII-A1AD8U189I 51152-88-6 PDSP1_001433 (+)-Mianserin BDBM35256 UEQUQVLFIPOEMF-GOSISDBHSA-N Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, (14bS)- MIANSERIN (-) ZINC855 A1AD8U189I PDSP2_001417 (S)-1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine DTXSID50199175 UNII-250PJI13LM component UEQUQVLFIPOEMF-GOSISDBHSA-N [ Show all ]
Inchi Key	UEQUQVLFIPOEMF-GOSISDBHSA-N
Inchi ID	InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3/t18-/m1/s1
PubChem CID	154315
ChEMBL	CHEMBL252719
IUPHAR	N/A
BindingDB	35256
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	100.0 nM	PMID7984267	BindingDB

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