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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Cannabinoid receptor 2
Species	Mus musculus (Mouse)
Gene	Cnr2
Synonym	Peripheral cannabinoid receptor mCB2 CB2-R CB2 receptor CB2 CB-2 cannabinoid receptor 2 (spleen) cannabinoid receptor 2 (macrophage) rCB2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	347
Amino acid sequence	MEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMGLLSALENMAVLYIILSSRRLRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHGVDSNAIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALCVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHRHVATLAEHQDRQVPGIARMRLDVRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLIGWKKYLQGLGPEGKEEGPRSSVTETEADVKTT
UniProt	P47936
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5373
IUPHAR	57
DrugBank	N/A

Ligand

Name	AM251
Molecular formula	C22H21Cl2IN4O
IUPAC name	1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide
Molecular weight	555.241
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	6.5
Synonyms	SR-01000597360-6 BCP9000280 BN0063 CCG-101124 DB-004430 HMS2052K15 J-011727 KS-0000180H 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidyl)pyrazole-3-carboxamide N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 2208AH RT-011260 AM 251 (pharmaceutical) AM251, >98% (HPLC), solid UNII-3I4FA44MAI Bio1_000608 BSPBio_001525 CHEMBL285932 FT-0661538 HMS3402M07 KBio2_005381 MFCD01861181 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide NC00374 4CA-0138 SB19550 SR-01000597360 BC600320 Bio2_000725 C22H21Cl2IN4O CTK8E9265 HMS1791M07 HY-15443 KBioGR_000245 MolPort-003-983-507 1H-Pyrazole-3-carboxamide,1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl- NCGC00025011-03 AKOS024456393 SW197754-2 BDBM21279 BRD-K92000912-001-02-7 CHEBI:90724 DTXSID7042695 HMS3267K22 KBio2_000245 L000964 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide s2819 AM-251 AM251/AM-251 ZINC1997139 Bio1_001097 BUZAJRPLUGXRAB-UHFFFAOYSA-N CPD000466284 GTPL3317 HMS3649G04 KBio3_000489 MLS000758233 183232-66-8 NCGC00025011-01 AC1L1CZ3 SCHEMBL1040316 SR-01000597360-1 BCP21728 BML3-F08 CBiol_001833 D08YQT HMS1989M07 IDI1_033995 KBioSS_000245 N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide NCGC00025011-04 AM 251 Tocris-1117 Bio1_000119 BRD-K92000912-001-06-8 EX-A696 HMS3394K15 KBio2_002813 LS-184236 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide N-Piperidino-1-(2,4-dichlorophenyl)-4-methyl-5-(4-iodophenyl)-1H-pyrazole-3-carboxamide 3I4FA44MAI SAM001247081 AOB33718 Bio2_000245 C20220 CS-3920 HMS1361M07 HMS3651B15 KBio3_000490 MLS001424171 1h-pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-n-1-piperidinyl- NCGC00025011-02 AC1Q5Q3V SMR000466284 [ Show all ]
Inchi Key	BUZAJRPLUGXRAB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
PubChem CID	2125
ChEMBL	CHEMBL285932
IUPHAR	3317
BindingDB	21279
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2290.0 nM	PMID10052983	BindingDB,ChEMBL

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