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Name | Muscarinic acetylcholine receptor M1 |
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Species | Rattus norvegicus (Rat) |
Gene | Chrm1 |
Synonym | cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 460 |
Amino acid sequence | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC |
UniProt | P08482 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL276 |
IUPHAR | 13 |
DrugBank | N/A |
Name | Otenzepad |
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Molecular formula | C24H31N5O2 |
IUPAC name | 11-[2-[2-(diethylaminomethyl)piperidin-1-yl]acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one |
Molecular weight | 421.545 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 2.0 |
Synonyms | NCGC00025002-02 Otenzepad, (+)- 102394-31-0 SCHEMBL341879 121029-35-4 [ Show all ] |
Inchi Key | UBRKDAVQCKZSPO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31) |
PubChem CID | 107867 |
ChEMBL | CHEMBL17045 |
IUPHAR | 309 |
BindingDB | 50018056 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 180.3 nM | PMID2547939 | BindingDB |
Ki | 398.11 nM | PMID2188581 | BindingDB |
Ki | 500.0 nM | PMID1310135 | BindingDB |
Ki | 501.187 - 1258.93 nM | PMID1325587, PMID2704370 | IUPHAR |
Ki | 740.0 - | PMID8421282 | ChEMBL |
Ki | 1200.0 nM | PMID1646322 | BindingDB |
Ki | 1300.0 nM | PMID2704370 | BindingDB |
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