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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	P2Y purinoceptor 14
Species	Mus musculus (Mouse)
Gene	P2ry14
Synonym	G protein-coupled receptor 105 G-protein coupled receptor 105 GPR105 G protein coupled receptor for UDP-glucose P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y UDP-glucose receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	338
Amino acid sequence	MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL
UniProt	Q9ESG6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1770046
IUPHAR	330
DrugBank	N/A

Ligand

Name	CHEMBL1771436
Molecular formula	C28H27N5O2
IUPAC name	N-(3-ethylphenyl)-4-(2-methoxyphenyl)-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
Molecular weight	465.557
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.0
Synonyms	N-(3-ethylphenyl)-4-(2-methoxyphenyl)-2-(pyridin-3-yl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide BDBM50343117
Inchi Key	TYUJLENLIPTJME-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H27N5O2/c1-3-19-8-6-10-21(16-19)30-28(34)33-15-13-24-23(18-33)26(22-11-4-5-12-25(22)35-2)32-27(31-24)20-9-7-14-29-17-20/h4-12,14,16-17H,3,13,15,18H2,1-2H3,(H,30,34)
PubChem CID	54582583
ChEMBL	CHEMBL1771436
IUPHAR	N/A
BindingDB	50343117
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3300.0 nM	PMID21507642	BindingDB,ChEMBL

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