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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Rattus norvegicus (Rat)
Gene	Npy5r
Synonym	food intake receptor neuropeptide Y receptor type 5 NPY-Y5 receptor NPY5-R NPYY5-R Y5 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
UniProt	Q63634
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2548
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL61488
Molecular formula	C19H19F3N2
IUPAC name	2-methyl-4-pyrrolidin-1-yl-6-[(E)-2-[3-(trifluoromethyl)phenyl]ethenyl]pyridine
Molecular weight	332.37
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	5.1
Synonyms	SCHEMBL7718221 2-Methyl-4-pyrrolidin-1-yl-6-[(E)-2-(3-trifluoromethyl-phenyl)-vinyl]-pyridine BDBM50073055 SCHEMBL7718212 2-[3-(Trifluoromethyl)styryl]-4-pyrrolizino-6-methylpyridine
Inchi Key	SVBPIHGFWPZCHM-BQYQJAHWSA-N
Inchi ID	InChI=1S/C19H19F3N2/c1-14-11-18(24-9-2-3-10-24)13-17(23-14)8-7-15-5-4-6-16(12-15)19(20,21)22/h4-8,11-13H,2-3,9-10H2,1H3/b8-7+
PubChem CID	9840567
ChEMBL	CHEMBL61488
IUPHAR	N/A
BindingDB	50073055
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4.1 nM	PMID9925722	BindingDB,ChEMBL

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