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Name | Glucagon receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | GCGR |
Synonym | GL-R GGR GR glucagon receptor |
Disease | Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes [ Show all ] |
Length | 477 |
Amino acid sequence | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF |
UniProt | P47871 |
Protein Data Bank | 5yqz, 5xez, 5ee7, 5xf1 |
GPCR-HGmod model | P47871 |
3D structure model | This structure is from PDB ID 5yqz. |
BioLiP | BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437 |
Therapeutic Target Database | T60182, T87875 |
ChEMBL | CHEMBL1985 |
IUPHAR | 251 |
DrugBank | N/A |
Name | CHEMBL197851 |
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Molecular formula | C28H32F3N7O3 |
IUPAC name | 4-[[8-tert-butyl-2-oxo-3-[4-(trifluoromethoxy)phenyl]-1,3-diazaspiro[4.5]decan-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamide |
Molecular weight | 571.605 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 5.5 |
Synonyms | BDBM50171836 SCHEMBL2665894 4-[8-tert-Butyl-2-oxo-3-(4-trifluoromethoxy-phenyl)-1,3-diaza-spiro[4.5]dec-1-ylmethyl]-N-(1H-tetrazol-5-yl)-benzamide SCHEMBL5946488 |
Inchi Key | BTHIALRARVMMLP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H32F3N7O3/c1-26(2,3)20-12-14-27(15-13-20)17-37(21-8-10-22(11-9-21)41-28(29,30)31)25(40)38(27)16-18-4-6-19(7-5-18)23(39)32-24-33-35-36-34-24/h4-11,20H,12-17H2,1-3H3,(H2,32,33,34,35,36,39) |
PubChem CID | 10370821 |
ChEMBL | CHEMBL197851 |
IUPHAR | N/A |
BindingDB | 50171836 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 105.0 nM | PMID16102966 | BindingDB,ChEMBL |
IC50 | 193.0 nM | PMID16102966 | BindingDB,ChEMBL |
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