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Name | Neuropeptide Y receptor type 5 |
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Species | Rattus norvegicus (Rat) |
Gene | Npy5r |
Synonym | food intake receptor neuropeptide Y receptor type 5 NPY-Y5 receptor NPY5-R NPYY5-R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 445 |
Amino acid sequence | MEFKLEEHFNKTFVTENNTAAARNAAFPAWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLQPSKKSRNQAKTPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQGKHLAVPENPASVRSQLSPSSKVIPGVPICFEVKPEESSDAHEMRVKRSITRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS |
UniProt | Q63634 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2548 |
IUPHAR | 308 |
DrugBank | N/A |
Name | CHEMBL557817 |
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Molecular formula | C29H30Cl2N4O3 |
IUPAC name | 2-[4-(5-chloro-2-oxo-4H-3,1-benzoxazin-1-yl)piperidin-1-yl]-N-(9-ethylcarbazol-3-yl)acetamide;hydrochloride |
Molecular weight | 553.484 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | None |
Synonyms | SCHEMBL3381361 |
Inchi Key | SICZVBKHDVFTIV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H29ClN4O3.ClH/c1-2-33-25-8-4-3-6-21(25)22-16-19(10-11-26(22)33)31-28(35)17-32-14-12-20(13-15-32)34-27-9-5-7-24(30)23(27)18-37-29(34)36;/h3-11,16,20H,2,12-15,17-18H2,1H3,(H,31,35);1H |
PubChem CID | 10437615 |
ChEMBL | CHEMBL557817 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 54.6 nM | PMID15771450 | ChEMBL |
Inhibition | 83.4 % | PMID15771450 | ChEMBL |
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