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GPCR

NameHistamine H2 receptor
SpeciesMus musculus (Mouse)
GeneHrh2
SynonymGastric receptor I
H2 receptor
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length397
Amino acid sequenceMEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
UniProtP97292
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2245
IUPHARN/A
DrugBankN/A

Ligand

Name103827-12-9
Molecular formulaC17H22N4O2
IUPAC nameN-[2-(1H-imidazol-5-yl)ethyl]-N'-(4-methylphenyl)pentanediamide
Molecular weight314.389
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP1.1
SynonymsCHEMBL303044
N~1~-[2-(1H-Imidazol-5-yl)ethyl]-N~5~-(4-methylphenyl)pentanediamide
ACMC-20m6mo
CTK0D8331
Pentanediamide, N-[2-(1H-imidazol-4-yl)ethyl]-N'-(4-methylphenyl)-
[ Show all ]
Inchi KeyBRUVXRVRSSLLEL-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H22N4O2/c1-13-5-7-14(8-6-13)21-17(23)4-2-3-16(22)19-10-9-15-11-18-12-20-15/h5-8,11-12H,2-4,9-10H2,1H3,(H,18,20)(H,19,22)(H,21,23)
PubChem CID13974562
ChEMBLCHEMBL303044
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency4.4 -PMID2959777ChEMBL

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