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GPCR

Name	Beta-2 adrenergic receptor
Species	Canis lupus familiaris (Dog)
Gene	ADRB2
Synonym	Beta-2 adrenoceptor Beta-2 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	415
Amino acid sequence	MGQPANRSVFLLAPNGSHAPDQGDSQERSEAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAKETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQLQKIDRSEGRFHAQNLSQVEQDGRSGHGHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSNNSNSRSDYAGEHSGCHLGQEKDSELLCEDPPGTEDRQGTVPSDSVDSQGRNCSTNDSLL
UniProt	P54833
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2289
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	norepinephrine
Molecular formula	C8H11NO3
IUPAC name	4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular weight	169.18
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	-1.2
Synonyms	ALBB-006229 X4W3ENH1CV (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2 Levonoradrenaline bmse000404 (R)-4-(2-Amino-1-hydroxyethyl)catechol NCGC00159406-04 CCG-40104 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)- NCGC00255328-01 d-Norepinephrine 21779-EP2287165A2 Noradrenalina DivK1c_000230 21779-EP2314571A2 Noreinefrina [INN-Spanish] FT-0603221 4786-EP2284171A1 Norepinephrine [INN:JAN] HSDB 7772 4786-EP2305677A1 Pharmakon1600-01500436 KBio3_001579 4899-05-2 SMR000058585 L-Noradrenaline AB00052424_08 STK503776 API0003193 (-)-Norepinephrine, >=98%, crystalline LS-42676 C-05156 025N592 NCGC00159406-07 CHEMBL1437 1,2-Benzenediol,4-(2-amino-1-hydroxyethyl)- Nor adrenalin (TN) D0R2UN 21779-EP2298731A1 Noradrenaline (JP15) DSSTox_RID_77004 4-[(1R)-2-amino-1-hydroxy-ethyl]benzene-1,2-diol GTPL505 4786-EP2287166A2 Norepirenamine IDI1_000230 4786-EP2308873A1 SBI-0050082.P003 l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol 51-40-1 (l-tartrate (1:1)) Spectrum2_001064 Levarterenolo Adrenor to_000024 (-)-(R)-Norepinephrine (-)-Arterenol free base Levoarterenol Benzyl alcohol, .alpha.-(aminomethyl)-3,4-dihydroxy-, (+)- (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol MLS006010883 CAS-51-41-2 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- NCGC00159406-10 D-(-)-Noradrenaline 21779-EP2272847A1 Noradrenalin DB00368 21779-EP2311828A1 Norartrinal EINECS 200-096-6 4786-EP2270011A1 Norepinephrine Noradrenalin HMS2091J08 4786-EP2305644A1 PDSP1_001111 KBio2_004057 4786-EP2314571A2 SFLSHLFXELFNJZ-QMMMGPOBSA-N L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol AB00052424-06 Spectrum5_001068 AKOS015854572 UNII-X4W3ENH1CV AN-24392 xi-Norepinephrine (-)-NORADRENALINE/ 1,?2-?Benzenediol, 4-?[(1R)?-?2-?amino-?1-?hydroxyethyl]?- Levonorepinephrine BRN 4231961 (R)-Noradrenaline NCGC00159406-05 CHEBI:18357 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(9CI) NINDS_000230 D00076 21779-EP2287166A2 Noradrenalina [Italian] DSSTox_CID_3378 21779-EP2377510A1 norepinefrina FT-0658803 4786-EP2287163A1 norepinephrinum HY-13715 4786-EP2305678A1 PubChem6074 KBioGR_000635 SPBio_001048 L-Norepinephrine AC1L96ZT Sympathin E (+)-Noradrenaline (-)-alpha-(Aminomethyl)protocatechuyl alcohol Arterenol (R)-( C)-Norepinephrine LT03330026 C-4015 1,2-Benzenediol, 4-((1R)-2-amino-1-hydroxyethyl)- NCGC00159406-08 CS-0007744 138-65-8 Nor-adrenaline D53D5E3A-2360-4CA9-8031-6C2CD4062FD5 21779-EP2298742A1 Noradrenaline (JP17) DTXSID5023378 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol Norepinephrine (INN) HMS1920B08 4786-EP2292620A2 NSC-757246 KBio1_000230 4786-EP2308875A1 SC-04955 l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol 51-41-2 Spectrum3_000520 AJ-09755 TR-005105 W-105896 (-)-NORADRENALINE Levonor Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (-)- (R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol NCGC00159406-03 CC-33071 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI) NCGC00159406-11 d-Arterenol 21779-EP2284170A1 Noradrenalin, l- DermX 21779-EP2311835A1 Noreinefrina FCH920095 4786-EP2280010A2 Norepinephrine [INN:BAN:JAN] HMS500L12 4786-EP2305648A1 PDSP2_001095 KBio2_006625 4786-EP2316836A1 SGCUT00123 L-arterenol AB00052424_07 Spectrum_001009 Aktamin ANW-74377 ZINC57624 (-)-Norepinephrine Levophed BSPBio_002079 (R)-Norepinephrine NCGC00159406-06 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- Nor adrenalin D07MOX 21779-EP2292620A2 noradrenaline DSSTox_GSID_23378 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol NOREPINEPHIRINE FT-0679201 4786-EP2287165A2 Norepinephrinum [INN-Latin] I01-15661 4786-EP2308864A1 R-norepinephrine KBioSS_001489 SPECTRUM1500436 Levarterenol Adrenaline Impurity Tox21_301944 (+)-Norepinephrine (-)-Arterenol Levarterenolo [DCIT] BDBM50029051 (R)-(-)-Norepinephrine MFCD00025592 C00547 1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)- NCGC00159406-09 CTK4C1344 21779-EP2269990A1 Nor-Epirenan 21779-EP2305669A1 Noradrenalinum Ecteinascidins 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol Norepinephrine l-Tartrate (1:1) HMS2089E18 4786-EP2298776A1 NSC757246 KBio2_001489 4786-EP2311831A1 SCHEMBL2609 L-3,4-dihydroxyphenylethanolamine 66197-73-7 Spectrum4_000078 AKOS006345192 UNII-K294OAI79V component SFLSHLFXELFNJZ-QMMMGPOBSA-N [ Show all ]
Inchi Key	SFLSHLFXELFNJZ-QMMMGPOBSA-N
Inchi ID	InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
PubChem CID	439260
ChEMBL	CHEMBL1437
IUPHAR	505
BindingDB	50029051
DrugBank	DB00368
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5000.0 nM	PMID10780918	ChEMBL
Ki	11000.0 nM	PMID10780918	BindingDB,ChEMBL
Ki	27000.0 nM	PMID10780918	ChEMBL

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