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Name | Histamine H1 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH1 |
Synonym | HH1R H1R Hisr H1 receptor |
Disease | Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder [ Show all ] |
Length | 487 |
Amino acid sequence | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS |
UniProt | P35367 |
Protein Data Bank | 3rze |
GPCR-HGmod model | P35367 |
3D structure model | This structure is from PDB ID 3rze. |
BioLiP | BL0202178, BL0202179, BL0202180 |
Therapeutic Target Database | T77913 |
ChEMBL | CHEMBL231 |
IUPHAR | 262 |
DrugBank | BE0000442 |
Name | CHEMBL1077862 |
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Molecular formula | C10H16N6 |
IUPAC name | 1-cyano-3-[4-(1H-imidazol-5-yl)butyl]-2-methylguanidine |
Molecular weight | 220.28 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 3 |
XlogP | 0.0 |
Synonyms | Guanidine, N-cyano-N'-[4-(1H-imidazol-4-yl)butyl]-N''-methyl- BDBM50415657 CTK1G2796 Guanidine, N-cyano-N'-[4-(1H-imidazol-5-yl)butyl]-N''-methyl- DTXSID90475147 [ Show all ] |
Inchi Key | SESBNJZEWNWYQM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C10H16N6/c1-12-10(15-7-11)14-5-3-2-4-9-6-13-8-16-9/h6,8H,2-5H2,1H3,(H,13,16)(H2,12,14,15) |
PubChem CID | 11983344 |
ChEMBL | CHEMBL1077862 |
IUPHAR | N/A |
BindingDB | 50415657 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
pKb | >5.0 - | PMID19791743 | ChEMBL |
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