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GPCR

NameD(1) dopamine receptor
SpeciesCarassius auratus (Goldfish)
Gene
SynonymDopamine D1 receptor
DiseaseN/A for non-human GPCRs
Length363
Amino acid sequenceMAVLDLNLTTVIDSGFMESDRSVRVLTGCFLSVLILSTLLGNTLVCAAVTKFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVTEVAGFWPFGAFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPRVAFVMISGAWTLSVLISFIPVQLKWHKAQPIGFLEVNASRRDLPTDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTQIYRIAQKQIRRISALERAAESAQIRHDSMGSGSNMDLESSFKLSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKRTSNGLPCISPTTFDVFVWFGWANSSLNPIIYAFNADFRRAFAILLGCQRLCPGSISMETPSLNKN
UniProtP35406
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2368
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL289867
Molecular formulaC19H23NO2S
IUPAC name(1S,10S)-15-butyl-16-thia-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-2,4,6,13(17),14-pentaene-4,5-diol
Molecular weight329.458
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP4.0
Synonyms(5aS,11bS)-2-Butyl-4,5,5a,6,7,11b-hexahydro-1-thia-5-aza-cyclopenta[c]phenanthrene-9,10-diol
BDBM50057845
SCHEMBL7007724
2-Butyl-4,5,5aalpha,6,7,11bbeta-hexahydro-1-thia-5-aza-1H-cyclopenta[c]phenanthrene-9,10-diol
Inchi KeySDSOUSANKZZJNT-YJBOKZPZSA-N
Inchi IDInChI=1S/C19H23NO2S/c1-2-3-4-13-7-12-10-20-15-6-5-11-8-16(21)17(22)9-14(11)18(15)19(12)23-13/h7-9,15,18,20-22H,2-6,10H2,1H3/t15-,18-/m0/s1
PubChem CID10830234
ChEMBLCHEMBL289867
IUPHARN/A
BindingDB50057845
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5044.0 nMPMID9171869BindingDB,ChEMBL
IA79.0 %PMID9171869ChEMBL

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