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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	AC1NT5A7
Molecular formula	C17H17NO3
IUPAC name	(NZ)-N-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-phenylpropylidene]hydroxylamine
Molecular weight	283.327
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	ZINC101266928 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-phenyl-1-propanone oxime MolPort-002-177-147 SR-01000224181-1 CHEMBL3189927 1-(2H,3H-benzo[3,4-e]1,4-dioxin-6-yl)-1-(hydroxyimino)-3-phenylpropane SMR000267781 AKOS024375895 ST51017320 (NZ)-N-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-phenylpropylidene]hydroxylamine MLS000681395 AB00101623-01 SR-01000224181 [ Show all ]
Inchi Key	AALSXVYLEMDJDV-SDXDJHTJSA-N
Inchi ID	InChI=1S/C17H17NO3/c19-18-15(8-6-13-4-2-1-3-5-13)14-7-9-16-17(12-14)21-11-10-20-16/h1-5,7,9,12,19H,6,8,10-11H2/b18-15-
PubChem CID	5345210
ChEMBL	CHEMBL3189927
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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